‘Snow flea protein’ could help improve organ preservationJuly 26th, 2008 - 4:54 pm ICT by IANS
Washington, July 26 (IANS) Scientists have found a way of creating antifreeze protein that helps billions of Canadian snow fleas survive frigid winters. These lab-produced proteins could have practical uses in extending the storage life of donor organs and tissues for human transplantation, according to new research.
In the study, Stephen B. H. Kent and colleagues pointed out that scientists tried to decipher the molecular structure and produce from chemicals so-called “snow flea antifreeze protein (sfAFP).
Those steps are critical for obtaining larger amounts of the protein, existing naturally in only minute quantities in snow fleas. The larger synthetic quantities can be used for further research and potential medical and commercial uses, they say.
The researchers made synthetic sfAFP, and showed that it has the same activity as the natural protein. They also produced variants, including one form of sfAFP with a molecular architecture that is the reverse, or “mirror image”, of natural sfAFP and different from any other protein found in living things on Earth.
The mirror-image form of sfAFP appears less likely to trigger harmful antibodies and more resistant to destruction by natural enzymes, making it potentially more effective than the native form for use in organ and tissue preservation, the scientists note.
“Our most significant advance was the use of the two mirror image forms of the protein to determine the previously unknown crystal structure of this unique protein,” said Kent. “That is a first in the history of protein X-ray crystallography.”
Tags: antibodies, antifreeze, billions, canadian snow, crystal structure, donor organs, frigid winters, further research, human transplantation, minute quantities, mirror image, molecular architecture, molecular structure, natural enzymes, natural protein, organ preservation, snow fleas, storage life, tissue preservation, x ray crystallography