High-flux hemodialysis prolongs kidney patients’ survivalFebruary 21st, 2009 - 2:55 pm ICT by IANS
London, Feb 21 (IANS) High-flux hemodialysis, which removes toxins of greater molecular size, reduces the risk of premature death in patients with chronic kidney disease or CKD, according to a study.
In patients with CKD, toxins accumulate in the blood because the kidneys lose their ability to eliminate these substances sufficiently.
CKD patients undergo either high-flux or low-flux hemodialysis to clear these toxins from the body (high-flux membranes have larger pores that allow for the removal of toxins of greater molecular size).
While studies have indicated that treatment with high-flux hemodialysis improved survival, the true potential of this treatment on prolonging life has not been clearly determined.
Francesco Locatelli, a doctor at A. Manzoni Hospital, Lecco, Italy, and his colleagues in eight European countries conducted a clinical trial to investigate the effect of high-flux hemodialysis on patient survival.
In a randomised clinical trial called the ‘membrane permeability outcome (MPO) study, they enrolled 738 hemodialysis patients and assigned them to either low-flux or high-flux hemodialysis, said a release of the American Society of Nehprology.
Patients were followed for 3 to 7.5 years. In the entire study group, the researchers did not detect a significant survival benefit with either high-flux or low-flux hemodialysis, but the use of high-flux membranes conferred a significant survival benefit in higher-risk patients. In addition, patients with diabetes showed a survival benefit with high-flux dialysis.
These findings could lead to potentially valuable clinical benefits for patients with CKD.
These findings will appear in the March issue of the Journal of the American Society Nephrology (JASN).
- Lower BP may be unhealthy for kidney patients, say expert - Jun 25, 2010
- Hemodialysis should be made affordable, say doctors - Mar 04, 2011
- Chronic kidney disorders threaten India's diabetics (March 10 is World Kidney Day) - Mar 10, 2011
- Sticking to a vegetarian diet may be good for kidney disease patients - Dec 24, 2010
- 'Diabetic patients with kidney failure need individualized care' - Jul 30, 2010
- Low levels of anti-aging hormone may be an indicator of kidney disease - Feb 19, 2011
- Exercise improves survival in kidney disease patients - Oct 09, 2009
- Childhood kidney disease linked to maternal diabetes, obesity - Nov 21, 2010
- Baking soda can slow chronic kidney disease progression - Jul 17, 2009
- Depression may increase kidney failure risk - Mar 11, 2011
- Daily dose of baking soda can save kidney - Jul 18, 2009
- Night home hemodialysis as good in treating kidney failure as transplant - Aug 21, 2009
- New blood test detects deadly calcium deposits - Sep 07, 2012
- Now, simple blood test to help predict chronic kidney disease - Oct 22, 2010
- Beefed-up muscles help kidney patients live longer - Oct 15, 2010
Tags: addition patients, chronic kidney disease, ckd, clinical trial, dialysis, european countries, hemodialysis patients, high flux, kidney patients, kidneys, lecco italy, london feb, manzoni, membrane permeability, patient survival, pores, premature death, risk patients, study group, survival benefit