Breakthrough opens way to stronger, more effective antibioticsOctober 2nd, 2008 - 4:53 pm ICT by IANS
Washington, Oct 2 (IANS) A new breakthrough opens the way for creation of less resistant and more effective antibiotics. “As bacteria become more resistant… our discovery provides a starting point for a completely novel class of antibiotics,” said John H. Bushweller, professor, molecular physiology, Virginia University (UV).
What Bushweller and fellow researchers at the UV and Harvard Medical School have determined is the structure of a particular integral membrane enzyme, called DsbB - one of the many proteins that reside in cell membranes.
These so-called integral membrane proteins are important, because they account for roughly a third of any genome in the human body and are the targets of more than half of all currently used drugs, according to an UV release.
Until now, scientists have been unable to acquire much structural information about these types of proteins; yet determining a protein’s structure is vital in order to understand how it functions and how it can potentially operate as a drug target.
Bushweller led study represents the first time scientists have cracked the code required to solve a certain class of membrane protein structure by using nuclear magnetic resonance (NMR) spectroscopy, the pre-eminent technique for determining the structure of organic compounds.
“What this means is that not only did we establish NMR spectroscopy as a potent tool for the characterisation of the structure, dynamics and function of integral membrane proteins, but we also discovered that the DsbB enzyme is an exciting… agent for the creation of novel antibiotics,” said Bushweller. “This could give us the roadmap to an entirely new class of antibiotics.”
These findings appeared in a recent issue of Molecular Cell.
- Groundbreaking discovery may lead to more effective antibiotics - Oct 02, 2008
- Disarming bugs can combat antibiotic resistance - Apr 05, 2012
- Pump that bacteria use to resist drugs described - Feb 27, 2011
- Chemical mechanism behind bugs' antibiotic resistance identified - Apr 29, 2011
- Deadly tool in Salmonella's bag of tricks identified - Feb 04, 2011
- Drugs checkmating cancer may combat resistant bugs - Dec 23, 2011
- New fluorescent biosensor to aid drug development - Jul 30, 2010
- Scientists use artificial, cell-like 'honey pots' to lure, trap deadly viruses - Mar 03, 2011
- Scientists crack protein code of killer parasite - Jan 09, 2012
- Study offers potential new targets for novel anti-HIV drugs - Mar 26, 2011
- Nanostructures lend cutting edge to antibiotics - Apr 04, 2011
- Scientists identify new strategy to control antibiotic resistance - Mar 19, 2011
- Scientists isolate molecule that helps produce proteins - Feb 15, 2011
- Antibiotic paves way for novel anti-cancer agents - Jan 29, 2011
- Bacterial defense mechanism code cracked - Apr 26, 2010
Tags: drug target, harvard medical school, integral membrane proteins, membrane protein structure, nmr spectroscopy, novel antibiotics, nuclear magnetic resonance, structure of organic compounds, types of proteins, university uv