Antibiotic dosing guidelines to help counteract superbugsJuly 5th, 2011 - 3:14 pm ICT by IANS
Sydney, July 5 (IANS) Doctors can now more confidently administer a drug that protects against bacterial superbugs, thanks to dosing guidelines for the antibiotic colistin.
Colistin treats serious infections in critically ill patients, including those with kidney failure who are receiving dialysis.
Developed by Monash University researchers, the guidelines will allow for more effective use of the drug and reduce the likelihood of bacteria developing resistance to it, the journal Antimicrobial Agents and Chemotherapy reports.
Professor Roger L. Nation and associate professor Jian Li, from the Monash Institute of Pharmaceutical Sciences, played a key role in initiating the international research effort that led to the current study, according to a Monash statement.
They said colistin was increasingly the last option available to treat seriously ill patients who have infections caused by an important class of antibiotic-resistant bacteria, known as gram-negative ’superbugs’.
“Unfortunately, colistin was developed more than 50 years ago when manufacturers were not required to provide accurate dosing guidelines. This has meant doctors are often shooting in the dark with respect to how much colistin should be administered to individual patients,” Nation said.
Insufficient dosage could leave patients vulnerable to infection and enable bacteria to become resistant, which could lead to more powerful superbugs in the future, he said.
The research team based the dosing formula on a study of 105 critically ill patients who were administered the antibiotic.
- Copper wins out in battle against MRSA - Apr 05, 2011
- Immunity boosting vitamin can fight superbugs - Aug 28, 2012
- Antibiotics ineffective against viral sinus infections - Mar 22, 2012
- Honey can help reverse bacterial resistance to antibiotics - Apr 13, 2011
- Gonorrhea cure gets tough as bug grows drug resistant - Nov 08, 2011
- Antibiotic-resistant superbugs 'could take us to pre-Penicillin era' - Apr 07, 2011
- Disarming bugs can combat antibiotic resistance - Apr 05, 2012
- Low doses of antibiotics can lead to multidrug resistance in 'superbugs' - Feb 12, 2010
- Scientists reveal how superbug turns killer - Oct 17, 2011
- Watch out for sexually transmitted 'superbug': Expert - Nov 01, 2011
- Disinfectants make hospital superbugs resistant to antibiotics - Dec 28, 2009
- Bugs filch copper to spread urinary infections - Jul 09, 2012
- Unique coating kills 99 percent bugs - May 11, 2012
- Don't undermine superbug's presence: Former ICMR chief - Oct 04, 2011
- WHO calls for dealing with multi-drug resistant microbes - Apr 07, 2011
Tags: , , , , , , , , , , , , , , , , , , ,