Salmonella-based shots hold promise against fatal diseasesJune 30th, 2011 - 6:45 pm ICT by IANS
Washington, June 30 (IANS) A powerful new class of vaccines, derived from Salmonella, holds great promise in fighting fatal diseases like hepatitis B, cholera, typhoid, AIDS and pneumonia.
Qingke Kong and his colleagues at the Arizona State University have developed a technique to make such vaccines, derived from Salmonella, which otherwise causes food poisoning, safer and more effective.
The group, under the direction of Roy Curtiss, chief scientist at Biodesign’s Centre for Infectious Diseases and Vaccinology at Arizona, demonstrated that a modified strain of Salmonella showed a five-fold reduction in virulence in mice, while bolstering immunity.
Streptococcus pneumoniae, a bacterium, causes community-acquired pneumonia, meningitis and bacteremia (presence of bugs in blood) and remains a leading killer. Childhood pneumonia alone claims three million lives annually, reports the Journal of Immunology.
Existing vaccines are inadequate for protecting vulnerable populations for several reasons. Heat stabilisation and needle injection are required, which are often impractical for mass inoculation efforts in the developing world, according to an Arizona State University statement.
Repeated doses are also needed to induce full immunity. Finally, the exorbitant costs of existing shots often deprive those who need them most, especially in poorer countries.
The problem is made worse by the recent emergence of antibiotic-resistant strains of pneumococcus, causing pneumonia.
The research was supported by grants from the Bill and Melinda Gates Foundation and the National Institute of Health.
- Vaccine made with synthetic gene shows promise against pneumonia - Feb 22, 2011
- Humanized mice paves way for better typhoid fever treatment - Sep 23, 2010
- New breakthrough paves way for vaccines against pneumonia, meningitis - Nov 12, 2010
- Bharat Biotech receives $4 million award for new vaccine - Jun 18, 2012
- Spacebound bacteria inspire earthly remedies - Mar 22, 2011
- Single dose salmonella vaccine to fight infant pneumonia - Jan 13, 2009
- Nasal spray vaccine for meningitis on the anvil - Jul 27, 2010
- Pneumonia vaccine offers protection to HIV patients - Mar 04, 2010
- Studying spacebound bacteria may inspire Earthbound remedies - Mar 22, 2011
- Anthrax shot protects simians from lethal infection - Jan 13, 2012
- Self-destructing microbe leads the way for lower-cost, renewable biofuels - Dec 08, 2009
- Vaccine reduces child cases of bacterial pneumonia: Study - Aug 28, 2010
- Vaccine to tackle meningitis 'just a year away' - Dec 24, 2010
- Deadly salmonella designed to administer vaccines in the body - Jul 09, 2008
- Salmonella-based vaccine candidates can help fight infant pneumonia - Jan 13, 2009
Tags: arizona state university, bacterium, bill and melinda gates, bill and melinda gates foundation, chief scientist, community acquired pneumonia, exorbitant costs, fatal diseases, hepatitis b, infectious diseases, inoculation, institute of health, melinda gates foundation, national institute of health, resistant strains, roy curtiss, streptococcus pneumoniae, vaccinology, virulence, vulnerable populations