Pollution could be turning you obese

December 2nd, 2008 - 1:30 pm ICT by IANS  

Washington, Dec 2 (IANS) A pollutant might be triggering obesity by influencing gene activity, according to a new study.For example tributyltin, a chemical is used in antifouling paints for boats, as a wood and textile preservative, and as a pesticide on high-value food crops, among many other applications.

Tributyltin affects sensitive receptors in animal cells, from water fleas to humans, at very low concentrations - a thousand times lower than pollutants that are known to interfere with sexual development of wildlife species.

Tributyltin and its relatives are highly toxic to snails, causing female snails to develop male sexual characteristics, and it bioaccumulates in fish and shellfish.

The harmful effects of the chemical on the liver and the nervous and immune systems in mammals are well known, but its powerful effects on the cellular components known as retinoid X receptors (RXRs) in a range of species are a recent discovery.

When activated, RXRs can migrate into the nuclei of cells and switch on genes that cause the growth of fat storage cells and regulate whole body metabolism — compounds that affect a related receptor often associated with RXRs are now used to treat diabetes.

RXRs are normally activated by signalling molecules found throughout the body.

Taisen Iguchi and Yoshinao Katsu of the Graduate University for Advanced Studies in Japan described how RXRs and related receptors are also strongly activated by tributyltin and similar chemicals.

Tributyltin impairs reproduction in water fleas through its effects on a receptor similar to the RXR. In addition, tributyltin causes the growth of excess fatty tissue in newborn mice exposed to it in the womb.

The effects of tributyltin on RXR-like nuclear receptors might therefore be widespread throughout the animal kingdom.

The rise in obesity in humans over the past 40 years parallels the increased use of industrial chemicals over the same period.

Iguchi and Katsu maintain that it is “plausible and provocative” to associate the obesity epidemic to chemical triggers present in the modern environment.

The study appeared in BioScience.

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