DNA sections linked to osteoarthritis foundJuly 3rd, 2012 - 3:39 pm ICT by IANS
London, July 3 (IANS) British researchers have discovered eight sections of our DNA that cause osteoarthritis, the hopelessly crippling condition affecting tens of millions worldwide.
The breakthrough by University of Newcastle scientists potentially opens the way to new therapies for the commonest form of arthritis, especially involving two or three of these genetic sections, responsible for the production of cartilage, the tissue between bones that is damaged by osteoarthritis.
Scientists also believe that they could alter patients’ genes to make them produce stronger cartilage, helping to repair the damaged joints, the journal Lancet reports.
Osteoarthritis is believed to affect as many as 40 percent of those over 70 years, causing debilitating joint pain — particularly in the hips and knees — and often leaves patients immobile or unable to walk long distances, according to the Daily Mail.
John Loughlin, Newcastle professor who led the research, said: “We’ve identified eight regions of human genomes that increase the risk of the disease. We would dearly like to use the information gathered to enable patients’ cells to be modified to ensure they make better cartilage. But it’s a long way off.”
At present, there is no known cure for the condition. Patients can only ease their symptoms with drugs, physiotherapy or in severe cases through surgery to remove the affected joint.
Researcher looked at 7,400 patients with osteoarthritis and compared their DNA to 11,000 people without the disease. They found eight sections of our DNA that are responsible for osteoarthritis.
Although the authors point out that it will be at least five or 10 years before they are close to a treatment, they described the findings as an important “first step”.
- New drug 'slows' oesteoarthritis progression - Mar 23, 2012
- New drug slows oesteoarthritis progression (Lead) - Mar 23, 2012
- New shot could reverse arthritis - Apr 08, 2012
- Grow your own tissue to mend arthritic knees - Nov 17, 2010
- Garlic can reduce risk of arthritis - Dec 19, 2010
- Arthritis can hit even the physically active (World Arthritis Day Oct 12) - Oct 11, 2010
- Osteoarthritis supplements have no impact on symptoms - Sep 17, 2010
- Surgeons conduct north India's first cartilage transplant - Nov 13, 2011
- A shot in six months can keep knee surgery at bay - Jun 03, 2011
- Indians beware - smoking can cause arthritis (Oct 12 is World Arthritis Day) - Oct 12, 2011
- Stem cell jab could replace hip, knee surgeries - Oct 18, 2010
- How deficiency of a protein results in fragile bones - Jul 28, 2010
- Heavy snoring doubles arthritis risk - Jun 28, 2012
- Garlic could protect against hip osteoarthritis - Dec 17, 2010
- Elderly people with clinical depression more prone to knee arthritis - Mar 17, 2011
Tags: arthritis, bones, british researchers, cartilage, daily mail, dna, genes, hips, human genomes, john loughlin, joint pain, joints, journal lancet, knees, long distances, mail john, osteoarthritis, physiotherapy, researcher, university of newcastle