Cheap diabetes drug could help fight breast cancer
April 15th, 2011 - 9:01 pm ICT by IANSLondon, April 15 (IANS) A low cost diabetes drug could benefit breast cancer sufferers.
Anthony Howell, director of the breakthrough breast cancer research unit at the University of Manchester, said: “We have some way to go but we hope that drugs like metformin will be saving lives of breast cancer patients over the next few years.”
Scientists have developed a new test that identifies patients who could benefit from the cheap treatment, reports the journal Cell Cycle.
They found that the people whose cancer cells “fed” off high-energy compounds were more likely to see their tumours spread than to die, the Telegraph reports.
This meant they could be helped by being given metformin, which stops the “fuel supply” for aggressive cancer cells.
Howell’s counterpart, Michael Lisanti at Manchester, said: “We’ve shown that the saying, ‘you are what you eat’ holds true for cancer. The food cancer cells consume is crucial to how well a patient does and what treatment they need.”
“However, patients could benefit from metformin, which cuts off this fuel supply. There is more work to do but this test could be an important new way of tailoring treatments to a patient’s needs, across a range of cancers.”
Last year it was reported that metformin was being tested to see if it can stop the growth of lung cancers.
Researchers from Manchester and Thomas Jefferson University in the US studied 219 breast cancer patients and worked out which ones had tumours that fed on high-energy foods, known as ketones and lactate, found in healthy cells.
- Personalized cancer medicine now a step closer to reality - Apr 16, 2011
- Scientists provide genetic evidence that antioxidants can help treat cancer - Feb 16, 2011
- Wonder drug could kill all types of cancer - Jun 27, 2011
- 'Low oxygen levels drive cancer growth' - May 06, 2012
- How cancer 'eats patients alive' - Sep 05, 2010
- 'Wonderdrug' keeps breast cancer away - Feb 25, 2011
- Diabetes drug reduces cancer risk - Nov 27, 2011
- Metformin may protect against liver cancer - Apr 02, 2012
- Why Tamoxifen fails to work on some breast cancer patients - Feb 24, 2010
- Diabetes drug may provide protection against endometrial cancer - Apr 06, 2011
- Circulating tumour cells in blood up death risk in early-stage breast cancer patients - Dec 11, 2010
- Silencing 'hedgehog' molecule halts cancer - Jun 06, 2011
- Genes linked to aggressive breast cancer identified - Aug 17, 2010
- Combo therapy may overcome Herceptin-resistant breast cancer - Mar 14, 2011
- Scientists stumble upon 'stop cancer' gene - Nov 16, 2011
Tags: aggressive cancer, anthony howell, breakthrough breast cancer, breast cancer, breast cancer patients, breast cancer research, breast cancer sufferers, cancer cells, cancer research unit, diabetes drug, energy foods, fight breast cancer, fuel supply, ketones, lactate, lisanti, lung cancers, metformin, thomas jefferson university, university of manchester