Biological clock of plants is sensitive to nutrient statusMarch 16th, 2008 - 12:02 pm ICT by admin
Washington, March 16 (ANI): An international team of researchers have identified that the master gene controlling the biological clock in plants is sensitive to nutrient status.
The study was conducted by a team of researchers at New York University’s Center for Genomics and Systems Biology, Chile’s Pontificia Universidad Catolica de Chile, Dartmouth College, and Cold Spring Harbor Labs.
For the study, the researchers took the case of the plant Arabidopsis.
Using a systems biological analysis of genome-scale data from Arabidopsis, the researchers identified that the master gene controlling its biological clock is sensitive to nutrient status.
This hypothesis derived from multi-network analysis of Arabidopsis genomic data, and validated experimentally, has shed light on how nutrients affect the molecular networks controlling plant growth and development in response to nutrient sensing.
According to Rodrigo A. Gutierrez and Gloria Coruzzi, the study’s lead authors, the systems biology approach to uncovering nutrient regulated gene networks provides new targets for engineering traits in plants of agronomic interest such as increased nitrogen use efficiency, which could lead to reduced fertilizer cost and lowering ground water contamination by nitrates.
Nitrogen is an essential nutrient and a metabolic signal that is sensed and converted, resulting in the control of gene expression in plants. In addition, nitrate has been shown to serve as a signal for the control of gene expression in Arabidopsis, the first flowering plant to have its entire genome sequenced.
There is existing evidence, on a gene-by-gene basis, that products of nitrogen assimilation, the amino acids glutamate (Glu) or glutamine (Gln), might serve as signals of organic nitrogen status that are sensed and in turn regulate gene expression.
To identify genome-wide responses to such organic nitrogen signals, the researchers treated Arabidopsis seedlings with inorganic nitrogen (N) in both the presence and the absence of chemicals that inhibit the assimilation into organic N and conducted a genome-wide analysis of all genes whose expression responds to inorganic or organic forms of nitrogen.
Using an integrated network model of molecular interactions for Arabidopsis - constructed by the researchers - in which approximately 7,000 genes are connected by 230,000 molecular interactions, they uncovered a sub-network of genes regulated by organic nitrogen that includes a highly connected network “hub” CCA1, which controls a plant’s biological clock, and target genes involved in nitrogen assimilation.
The findings thus provide evidence that plant nutrition, like animal nutrition, is tightly linked to circadian, or biological clock, functions as scientists have previously hypothesized.
This study indicates that nitrogen nutrition affects CCA1, the central clock gene of plants, suggesting nutritional regulation of the biological clock occurs in plants. (ANI)
- Similar gene controls plant, human clocks - Dec 02, 2010
- Hidden DNA code more influential than our genes - Sep 19, 2011
- Plants adapt genetically to survive unfavourable environments - Feb 01, 2011
- New mechanism regulating body's 24-hour clock identified - Nov 12, 2010
- Male, female parts in plants 'talk in the same way as cells do in your brain' - Mar 18, 2011
- Tweaking plants' bio-clock can revolutionise food output - Sep 04, 2011
- Scientists discover key missing link in signaling pathway for plant steroid hormones - Sep 09, 2009
- Ecosystems overloaded with nitrogen, courtesy humans - Oct 08, 2010
- Genome analysis of marine microbe reveals a metabolic minimalist - Feb 22, 2010
- Newly sequenced strawberry genome decoded - Dec 27, 2010
- Worms provide insights into human biological clock - Dec 18, 2010
- Breastfeeding key to keeping infant gut healthy - Apr 30, 2012
- Study reveals links to abnormal rhythms behind sudden death, heart damage - Dec 21, 2010
- Gene discovery could lead to healthier food, better biofuel production - Nov 23, 2010
- Why some plants flower in spring while others in summer - Jun 30, 2010
Tags: biological clock, cold spring harbor, cold spring harbor labs, control of gene expression, dartmouth college, gene by gene, gene networks, ground water contamination, master gene, molecular networks, new york university, nitrogen assimilation, nitrogen status, nutrient status, organic nitrogen, plant growth and development, pontificia universidad catolica, pontificia universidad catolica de chile, systems biology, universidad catolica de chile