Scientists identify gene linked to biological ageing in humansFebruary 8th, 2010 - 4:04 pm ICT by IANS
London, Feb 8 (IANS) Scientists have identified specific genetic variants associated with biological ageing in humans.
Biological ageing, as distinct from chronology ageing, includes changes in the physical structure of the body as well as changes in the performance of motor skills and sensory awareness.
The team analysed more than 500,000 genetic variations, across the entire human genome, to identify the variants which are located near a gene called TERC.
These findings were done by researchers from the University of Leicester (U-L) and King’s College London, working with University of Groningen in the Netherlands.
Nilesh Samani, cardiology professor at U-L, who co-led the project, explained that there are two forms of ageing — chronological ageing i.e. how old you are in years and biological ageing whereby the cells of some individuals are older (or younger) than suggested by their actual age.
“There is accumulating evidence that the risk of age-associated diseases including heart disease and some types of cancers are more closely related to biological rather than chronological age,” said Samani.
“What we studied are structures called telomeres which are parts of one’s chromosomes. Individuals are born with telomeres of certain length and in many cells telomeres shorten as the cells divide and age. Telomere length is therefore considered a marker of biological ageing.”
“In this study what we found was that those individuals carrying a particular genetic variant had shorter telomeres i.e. looked biologically older,” said Samani.
These findings were published in Nature Genetics today.
- Genetic variant linked to ageing in humans identified - Feb 08, 2010
- Chronic depression linked to accelerated immune cell aging - Apr 06, 2011
- Excessive alcohol consumption linked to increased cancer risk - Apr 22, 2010
- DNA bits could help understand development of diseases - Jun 12, 2010
- Genetic variation that cuts bladder cancer risk identified - Apr 03, 2011
- New blood test can predict how long one will live - May 16, 2011
- New DNA study may offer insights into several diseases - Jun 12, 2010
- Scientists unlock secrets of cancer-driving enzyme - May 08, 2011
- Kids who face violence age faster - Apr 25, 2012
- Biological aging markers 'up cancer risk' - Jul 07, 2010
- Exercise can reduce impact of stress on cell aging - May 27, 2010
- Excessive alcohol intake may increase cancer risk - Apr 22, 2010
- Physical activity may prevent stress on telomeres - Apr 05, 2011
- New genetic variants linked to height identified - Dec 31, 2010
- Offspring of older fathers may live longer - Jun 12, 2012
Tags: ageing, chromosomes, chronological age, college london, genetic variant, genetic variants, genetic variations, human genome, london feb, nature genetics, nilesh, physical structure, s college, samani, sensory awareness, structure of the body, telomeres, types of cancers, university of groningen, university of leicester