Protein that helps salamanders re-grow limbs identifiedNovember 14th, 2007 - 8:20 am ICT by admin
The scientists say that when a newt or other amphibian loses a limb, stem cells in the region grow and divide at the tip of the stump, where the limb was once attached, to form a larger mass of cells called blastema.
“Those cells grow and divide and they give rise to the structures that have been amputated. So if you amputate at the wrist, those cells will give rise to a hand; if you amputate at the shoulder, they’ll give rise to an arm,” LiveScience quoted study team member Jeremy Brockes, of the University College London, as saying.
During the study, the researchers chopped off red-spotted newts’ limbs and the attached nerves, which are needed to stimulate the production of the nAG protein.
The researchers then zapped the cells of the now-exposed body region with electrical pulses so that they could deliver little bundles of DNA carrying genes for the protein nAG.
The newts’ limbs were regenerated within 30 to 40 days, but the new limbs had less muscle mass than the original ones.
Upon conducting further lab experiments, the researcher observed that the nAG protein works directly on the blastema cells, causing them to grow and divide.
Brockes, however, has admitted that it is too early to say that human-limb regeneration is right around the corner.
“What everybody is interested in, of course, are things about the extension to humans. I’m really very cautious about that,” he said.
He also revealed that in order to move one step further towards limb regeneration in humans, scientists needed to figure out whether there exists human equivalent to the blastema that salamanders form after a limb gets amputated.
“I don’t think we generate those (blastema) cells after injury in a way that a newt does,” Brockes said. (ANI)
- Lizard enzyme could let humans regrow organs, limbs - Dec 07, 2010
- Regrowing lost limbs may soon be a reality - Aug 05, 2010
- Human tissue regeneration hope following successful experiment in mice - Aug 06, 2010
- How dopamine controls the formation of new neurons in adult brain - Apr 09, 2011
- Salamanders can regenerate lost limbs, damaged lungs - Jul 02, 2009
- Patients' own stem cells could be used as treatment for their heart disease - Nov 18, 2010
- Humans may one day be able to regrow organs and limbs - Feb 20, 2010
- 'Holy Grail' of regenerative medicine found? - Nov 04, 2009
- Worms may harbour human limb regeneration secrets - Apr 24, 2010
- Protein that controls liver stem cells, prevents tumor development found - Aug 13, 2010
- Scientists 'successfully regenerate human taste cells in a dish' - Apr 07, 2011
- Soon, stem cells to help repair brain damage - Apr 14, 2010
- Scientists develop toothy way to treat spinal injuries - Dec 04, 2011
- New study paves for novel treatments for regenerating liver, bone marrow - Nov 13, 2010
- Genetic switch that controls tissue regeneration found - Feb 04, 2011
Tags: anoop, cautious, electrical pulses, human equivalent, human limb, journal science, lab experiments, limb regeneration, livescience, move one, protein, red spotted newts, regenerative medicine, salamanders, scientists, stem cells, university college london