Missing enzyme protects mice from effects of heart attacksApril 6th, 2009 - 5:27 pm ICT by IANS
Washington, April 6 (IANS) Mice born without a certain enzyme can resist the effects of a heart attack, still retaining near normal cardiac function, according to a study.
The scientists found that in mice, lacking the enzyme GNSOR (or S-nitrosoglutathione reductase), the blood was able to get around the blockage point that normally would cut off blood to the heart because of remarkable capillary growth in these animals.
“There were blood vessels everywhere in these mice born without the enzyme,” said Jonathan Stamler, a Duke University Medical Centre (DUMC) professor of medicine and biochemistry and study co-author.
The findings raise the possibility of a therapy that could stimulate the growth of blood vessels and limit damage from a heart attack as well as prevent an attack from occurring at all, the scientists said.
Normal mice (with the enzyme) in the same experiment had full heart attacks, suffering damage to their heart pumps and a lack of oxygen in their heart tissues, which are typical effects of a heart attack.
“The hope is that this discovery someday could result in a therapy for new blood vessel growth that could be a sort of natural bypass in humans. Perhaps it could also benefit patients with peripheral artery disease, who cannot walk, for example, but who might be able to grow new blood vessels in their legs,” said Stamler.
“Normally if you block the major artery to a heart, oxygen tension drops in the tissues - you can’t get oxygen to the tissues and they die,” Stamler said, according to a Duke release.
The study was published in the Proceedings of the National Academy of Sciences online.
- Protein that could be new target to reduce damage after heart attack identified - Feb 25, 2011
- Root cause of blood vessel damage in people with diabetes discovered - Jan 29, 2011
- Garlic oil component protects heart - Nov 17, 2011
- Chronic inhalation of polluted air 'can lead to inflammation, heart risk' - Apr 17, 2011
- Vaccines for heart attacks to be ready within 5 years - Apr 01, 2012
- Spitting debris helps brain's tiny blood vessels survive - Jun 05, 2010
- Targeting fatty acids in immune cells may cut atherosclerosis risk - Jul 24, 2010
- New technique to identify potential atherosclerosis risk found - Apr 12, 2011
- Pain killers retard recovery from heart attack - Apr 09, 2012
- Simple jab could limit heart attacks and stroke damages - Apr 19, 2011
- Why our red blood turns blue after entering veins - Aug 29, 2009
- Growing new arteries could lead to 'biological bypass' for heart disease - Mar 09, 2010
- Growing arteries could lead to 'biological bypass' - Mar 09, 2010
- Chemical in plastic bottles aggravates heart risk - Aug 16, 2012
- Mole-rats' secret can help brain survive in oxygen scarcity - Feb 27, 2012
Tags: blood vessel growth, cardiac function, duke university medical, duke university medical centre, dumc, effects of a heart attack, heart attack, heart attacks, heart pumps, jonathan stamler, lack of oxygen, national academy of sciences, new blood, nitrosoglutathione, oxygen tension, peripheral artery disease, proceedings of the national academy, proceedings of the national academy of sciences, typical effects, university medical centre