Thaindian News

London, Oct 7 (IANS) Indian-born scientist Venkatraman Ramakrishnan shares the Nobel Prize in Chemistry this year with Thomas A. Steitz and Ada E. Yonath, it was announced in Stockholm Wednesday.
The Royal Swedish Academy of Sciences said the Nobel Prize in Chemistry for 2009 awards studies of one of life’s core processes: the ribosome’s translation of DNA information into life.

Ribosomes produce proteins, which in turn control the chemistry in all living organisms. As ribosomes are crucial to life, they are also a major target for new antibiotics, it said in a statement.

Born in 1952 in Chidambaram, Tamil Nadu, Ramakrishnan did his PhD in Physics in 1976 from Ohio University, US. He is a senior scientist and group leader at Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge, Britain.

When he was reached by Swedish radio’s science desk, Ramakrishnan said he had not had the time to inform his wife about the news, DPA reported.

Ramakrishnan and Steitz are US citizens while Yonath is from Israel.

Ramakrishnan joins an illustrious list of Indians and people of Indian origin who have won the Nobel Prize in various disciplines — including Rabindranath Tagore, C.V. Raman, Hargobind Khorana, Mother Teresa, S. Chandrashekhar and Amartya Sen.

The trio have been awarded for showing what the ribosome looks like and how it functions at the atomic level. All three have used a method called X-ray crystallography to map the position for each and every one of the hundreds of thousands of atoms that make up the ribosome.

“Inside every cell in all organisms, there are DNA molecules. They contain the blueprints for how a human being, a plant or a bacterium, looks and functions. But the DNA molecule is passive. If there was nothing else, there would be no life,” a statement from the academy of sciences said.

The blueprints become transformed into living matter through the work of ribosomes.

An understanding of the ribosome’s innermost workings is important for a scientific understanding of life. This knowledge can be put to a practical and immediate use; many of today’s antibiotics cure various diseases by blocking the function of bacterial ribosomes. Without functional ribosomes, bacteria cannot survive. This is why ribosomes are such an important target for new antibiotics, the statement added.

This year’s three Laureates have all generated 3D models that show how different antibiotics bind to the ribosome. These models are now used by scientists in order to develop new antibiotics, directly assisting the saving of lives and decreasing humanity’s suffering.

Yonath, who is with the department of structural biology at the Weizmann Institute of Science in Israel, said the discovery was made some seven, eight years ago, and she “did not expect” the prize, she told Swedish radio’s science desk.

Steitz, professor of molecular biophysics at Yale University, Connecticut, said he was preparing to go the gym when the call with the prize announcement came from Stockholm.

“My caller from Stockholm said I shouldn’t go to the gym. There would be phone calls,” Steitz, born 1940, was quoted as saying.

The Chemistry prize was the third of this year’s Nobel Prizes to be announced following the Medicine prize Monday and the Physics Tuesday.