Cancer drug may help treat manic bipolar disorderMarch 4th, 2008 - 12:29 pm ICT by admin
London, March 4 (IANS) Tamoxifen, a drug typically used in treating breast cancer, could possibly decrease symptoms of mania in cases of bipolar depression too, a new study contends. A low-key, three-week trial of the drug showed promising results, according to a report in the latest issue of the journal Archives of General Psychiatry.
Tamoxifen interferes with effects of oestrogen, a hormone that also accounts for similar outcomes against breast cancer, according to the article.
However, tamoxifen also inhibits actions of a family of enzymes known as protein kinase C. Abnormal levels of activity by these enzymes have been associated with bipolar disorder and related dysfunctions, such as distractibility, impaired judgements and disorganised thoughts.
Animal studies and human pilot trials have suggested that tamoxifen may be effective in treating bipolar mania. It is an abnormally elevated mood that features impulsive behaviour, higher energy and activity levels, and disconnected thoughts.
Tags: abnormal levels, animal studies, archives of general psychiatry, bipolar, bipolar disorder, breast cancer, cancer drug, depression, enzymes, higher energy, human pilot, impulsive behaviour, journal archives, judgements, london march, manic bipolar, pilot trials, promising results, protein kinase c, tamoxifen