Protein that makes food-borne bacteria resistant to antibiotics identifiedJune 6th, 2008 - 4:44 pm ICT by ANI
Washington, June 6 (ANI): Iowa researchers have identified a protein that makes common food borne bacteria resistant to antibiotics.
The team led by Dr. Qijing Zhang has found Mfd, a protein involved in DNA transcription and repair that plays an important role in the development of fluoroquinolone antibiotic resistance in Campylobacter, a bacterial pathogen associated with food poisoning in humans.
Previous studies have revealed that Campylobacter is highly mutable to antibiotic treatment and the number of fluoroquinolone-resistant Campylobacter is greatly increased in many regions of the world.
But it has not been clear why Campylobacter is able to mutate at such a high frequency.
With the help of various molecular tools, the research team from the College of Veterinary Medicine found that Campylobacter increases the production of Mfd in the presence of a fluoroquinolone antibiotic.
Elimination of Mfd from Campylobacter resulted in 100-fold reduction in the rate of emergence of mutants resistant to fluoroquinolones.
Without Mfd, the development of fluoroquinolone-resistant Campylobacter under antibiotic treatment was significantly reduced.
The study is published in June 6 th open-access journal PLoS Pathogens (ANI)
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Tags: antibiotic resistance, antibiotic treatment, antibiotics, bacterial pathogen, campylobacter, college of veterinary medicine, dna transcription, emergence, food borne bacteria, food poisoning, high frequency, iowa researchers, medicine, molecular tools, mutants, open access, presence, protein, regions of the world