The first 3-D view of anti-cancer agent developedMarch 19th, 2008 - 4:04 pm ICT by admin
Washington, Mar 19 (ANI): The first three-dimensional image of how a well-established chemotherapy agent targets and binds to DNA has been created. This scientists say, might help develop better chemotherapy drugs to treat a wide range of cancers.
Scientists at the Indiana University School of Medicine and the Purdue School of Science at Indiana University-Purdue University Indianapolis used X-ray crystallography, which helped them produce the first 3-D molecular level images of bleomycin bound to DNA.
X-ray crystallography is a widely used analytical technique in which X-rays are directed through crystals and results are deduced from the pattern of diffraction of the X-rays.
Although bleomycin has been studied for 40 years and much is known about the mechanism of action of bleomycin, without an accurate 3-D picture you cant fully understand how the drug targets and sits on the DNA. If you want to improve on the properties of the drug, to make it a better chemo agent, you need to understand in great detail how it works, said Millie M. Georgiadis, Ph.D., associate professor of biochemistry and molecular biology at the IU School of Medicine and at the Purdue School of Science.
Our 3-D picture of the structure of bleomycin gives us a much better understanding of exactly how the drug interacts with the DNA so we can begin thinking about engineering a better drug, with less toxicity. Since its a DNA targeting agent, theres no limit to what type of cancers we could target with bleomycin if we can decrease the toxicity, said Dr. Georgiadis, a structural biologist.
The study is published in the Early Edition of the Proceedings of the National Academy of Sciences. (ANI)
Tags: biochemistry and molecular biology, bleomycin, cancer agent, chemo agent, chemotherapy drugs, drug targets, georgiadis, indiana university purdue, indiana university school, indiana university school of medicine, iu school of medicine, national academy of sciences, proceedings of the national academy, proceedings of the national academy of sciences, purdue school, purdue university indianapolis, three dimensional image, type of cancers, x ray crystallography, x rays