Specific white blood cell subset expansion may be HIV progression biomarker

March 28th, 2008 - 4:14 pm ICT by admin  

Washington, Mar 28 (ANI): According to the researchers at the Temple University, an increase in a specific white blood cell subset could be a biomarker for the progression of HIV disease.

Monocyte is a specific white blood cell, a part of the human bodys immune system that protects against blood-borne pathogens and moves quickly to sites of infection within the bodys tissues.

As monocytes enter tissue, they undergo a series of changes to become macrophages.

The researchers were investigating alterations in the CD163+/CD16+ monocyte subset in patients with HIV infection. As part of this study, they examined a cohort of 18 patients from the Comprehensive HIV Program at Temple University Hospital, under the direction of Ellen Tedaldi, and seven individuals without HIV infection.

At first, we were just looking at whether or not we saw alterations in this CD163+/CD16+ subset and whether it might be reflective of the amount of virus they have in circulation, said Tracy Fischer-Smith, an associate scientist in Temples Neuroscience Department and the studys lead author.

We did, indeed, find that patients with detectable virus had an increase of this monocyte subset that correlated with the amount of virus they had in their blood. We were surprised to find that patients with CD4+ T cell counts of less than 450 cells per microliter [200 or less per microliter is defined as AIDS], the increase of this monocyte subset correlates inversely with the number of T cells, Fischer-Smith said.

The finding suggests that as the monocyte cells are increasing, these patients are losing CD4+ T cells, which are critical for the maintenance of immunological competence, said Fischer-Smith.

This may actually provide an earlier window into what is happening with HIV-infected patients where we might be able to see that immune impairment is taking place before we see a dramatic loss of CD4+ T cells, she said.

It looks like, based on these correlations, that this particular cell type may be involved in immune impairment and the progression of HIV, said Jay Rappaport, professor of neuroscience and neurovirology, who oversaw the study.

Is it a good prognostic indicator” If you have a lot of these monocytes, does it mean you are going to progress into AIDS faster” Right now, all we know is what the correlations are, he said.

Rappaport added that he believes the CD163+/CD16+ monocyte subset is the first biomarker that correlates with viral load and CD4+ count.

The fact that it actually correlates with both, we think, might make it a key cell type in the pathogenesis of AIDS.

The study CD163/CD16 Coexpression by Circulating Monocytes/Macrophages in HIV: Potential Biomarkers for HIV Infection and AIDS Progression, is published in AIDS Research and Human Retroviruses. (ANI)

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