Self-assembling nano-fibre gel for delivering drugs in high concentrationsOctober 22nd, 2008 - 6:22 pm ICT by ANI
Washington, Oct 22 (ANI): A research team, involving an Indian origin scientist, has developed a new self-assembling hydrogel drug delivery system that can ill not only deliver clinically approved drugs in high concentrations, but also do away with any toxic residue in the process.
Developed by scientists from Harvard-MIT Division of Health Science and Technology (HST) at Brigham and Women’’s Hospital, the system is biocompatible, efficient at drug release, and is also easy to tailor.
The structures will do way with carriers for the drug or generating toxic componentsa problem encountered with hydrogel systems until now.
“This strategy could serve as the platform technology for developing drug-based delivery carriers that can release drugs such as anti-inflammatory agents on demand in response to inflammation, for example,” said Jeffrey Karp, MD, instructor of medicine at the HST Center for Biomedical Engineering at the Brigham and Women’’s Hospital and a co-corresponding author on this manuscript.
“Converting known, clinically-practicing drugs into amphiphilic molecules which can undergo self-assembly is the key development in our present research; this may eliminate the need for an external carrier for delivering drugs” said Praveen Kumar Vemula, PhD, research fellow in medicine at Brigham and Women’’s Hospital.
“Enzyme triggered gel degradation has been our key strength, which played a major role in developing these delivery vehicles from drugs-based hydrogels” said another leading investigator Dr. George John, who is associate professor at City College of New York. Gregory Cruikshank.
The findings, which are now available on Science Direct, will be published in the Nov. 25 issue of Biomaterials. (ANI)
- Injectable gel offers hope for arthritis sufferers - Apr 14, 2011
- Injectable gel could ease crippling joint pains - Apr 14, 2011
- Nanoparticles could offer relief from rashes - Apr 04, 2011
- Eavesdropping on cells' chats with nano-sensors - Jul 18, 2011
- Biocompatible gel to replace damaged cartilage - Sep 06, 2012
- Soon, nasal spray vaccine to fight Alzheimer's, stroke - Mar 01, 2011
- Nanoparticles could offer relief from skin allergies - Apr 04, 2011
- Ibuprofen may reduce risk of Parkinson's disease - Mar 03, 2011
- Novel hydrogel regenerates burnt skin tissues - Dec 14, 2011
- Ideal Cures unveil new technology to prolong drug release - Jul 23, 2012
- New technology may free diabetics from daily injections - Aug 14, 2012
- New needle could cut medical complications - Apr 03, 2009
- Scientists create DNA engine that can be observed in real-time - Feb 07, 2011
- Chemicals in cosmetics may spike diabetes risk - Jul 15, 2012
- Growth-factor-containing nanoparticles speed up healing of chronic wounds - Jan 27, 2011
Tags: amphiphilic molecules, brigham and women, city college of new york, delivery carriers, delivery vehicles, dr george, drug delivery system, health science, hst, indian origin, inflammatory agents, jeffrey karp, key development, platform technology, present research, research fellow, s hospital, science direct, self assembly, toxic residue