Scientists find strong evidence linking genetics to migraine susceptibilityApril 18th, 2008 - 4:00 pm ICT by admin
Washington, April 18 (ANI): A study on two diverse populations of Finnish and Australian people has uncovered the first conclusive evidence linking genetics to migraine susceptibility.
Professor Aarno Palotie, who is associated with both Finland-based University of Helsinki and the UK-based Sanger Institute, says that his team used a new analysis technique in the study, which concentrates on different symptoms of migraine.
He revealed that the study included 1700 migraine patients and their close relatives from 210 Finnish and Australian migraine families.
The researcher further said that the initial genome-wide micro-satellite study was followed up by an independent targeted replication study.
Palotie said that the research unveiled one gene locus on chromosome 10q23, which showed significant evidence of genetic linkage in both populations studied as well as in the replication study.
The gene locus was especially strongly linked to female migraine patients, say the researchers.
In a further analysis, two independent previous studies, one Finnish and one Australian, had detected the same locus, but in those studies the level of evidence had been just below significance, and thus the connection had so far been missed, says Verneri Anttila, a researcher from Paloties group.
The locus is thus linked to migraine in a total of 4000 migraine patients or their close relatives.
All of these findings depended on the newly discovered aspect of migraine genetics: different types of pain such as pain that pulsates or pain that is unilateral are more closely linked to specific genetic loci than general pain, Palotie says.
The studys findings are important because Finland and Australia are genetically distant, according to the researchers.
What signifies the robustness of evidence pinpointing the susceptibility region is the fact that the study tied together previous researchthe Finnish families had been ascertained through neurology clinics, while the Australian families had been collected through a twin study.
This study is the first international collaboration as well as the largest linkage study in migraine to date. It successfully applied new analysis strategies in detecting the locus and thus paved the way for subsequent large association studies, Palotie and Anttila say.
The researcher duo says that the study gives new hope to deciphering the migraine pathways, and therefore discovering targets for future treatments and the first migraine gene variants. (ANI)
- First genetic link to common migraine found - Aug 30, 2010
- Scientists identify genes linked with migraine risk - Aug 30, 2010
- Genes linked to migraine discovered - Jun 13, 2011
- Migraines do not hurt your brain - Aug 12, 2012
- Why some are more susceptible to pain than others - Aug 05, 2010
- Gene related to chronic pain discovered - Aug 06, 2010
- Genes linked to throat cancer identified - May 31, 2010
- 'Know your genes to live hale and hearty' - Jan 11, 2012
- Weight loss surgery can help alleviate migraines - Mar 29, 2011
- Chinese scientists make headway in leprosy prevention - Jan 30, 2012
- Four new psoriasis 'hotspots' identified - Oct 19, 2010
- Scientists identify genetic link to suicidal behaviour - Oct 09, 2011
- 13 genes behind heart disease uncovered - Mar 07, 2011
- Genes help determine our susceptibility to depression - Jan 04, 2011
- Study sheds new light on the causes of chronic liver cirrhosis - Mar 14, 2011
Tags: chromosome 10q23, close relatives, conclusive evidence, gene locus, genetic linkage, genetic loci, genetics, level of evidence, micro satellite, migraine, migraine patients, populations, replication study, researcher, robustness, sanger institute, scientists, susceptibility, symptoms of migraine, university of helsinki