Scaffolds may soon help heal broken heartsNovember 3rd, 2008 - 1:14 pm ICT by ANI
London, Nov 3 (ANI): Researchers from the Massachusetts Institute of Technology (MIT) have developed a new technique that may one day help in mending damaged heart tissues.
The team has developed a novel scaffold, on which it claims to place living heart cells or stem cells that would later develop into a patch of cardiac tissue that could be used to treat congenital heart defects, or aid the recovery of tissue damaged by a heart attack.
The biodegradable scaffold would be gradually absorbed into the body, leaving behind new tissue.
The researchers claim that the accordion-like honeycomb scaffold has various advantages over previous cardiac tissue engineering scaffolds.
Further, the MIT team’’s general approach has applications to other types of engineered tissues.
“In the long term we”d like to have a whole library of scaffolds for different tissues in need of repair,” Nature magazine quoted Lisa E. Freed, corresponding author of the paper and a principal research scientist in the Harvard-MIT Division of Health Sciences and Technology (HST), as saying.
Heart muscle is “directionally dependent” i.e. its cells are aligned in specific directions.
The new scaffold has been designed with the help of a laser similar to that used for eye surgery, to match the structural and mechanical properties of native heart tissue.
The scaffold has three principal advantages over its predecessors. First, its mechanical properties closely match those of native heart tissue. For example, it is stiffer when stretched circumferentially as compared to longitudinally.
Secondly, a patch of tissue created from neonatal rat heart cells cultured on the scaffold showed directionally dependent electrophysiological properties similar to native tissue. In other words, when an electrical field was applied the engineered patch contracted more readily in one direction than in another.
And finally, “the scaffold itself has an intrinsic ability to guide the orientation of cultured heart cells,” Freed said.
The research appears in Nature Materials. (ANI)
- Repairing defective hearts with tissue engineering - Nov 03, 2008
- New anti-wrinkle biomaterial mimics human tissue - May 30, 2011
- Scientists think of new way of creating synthetic tissues - May 17, 2010
- Tasar silk could help heal damaged hearts - Jan 30, 2012
- New way to assemble artificial tissues developed - May 14, 2010
- Injectable gel to heal damaged hearts - Feb 22, 2012
- MIT geeks build chip to mimic brain cell - Nov 16, 2011
- New scaffold designed to fix a broken heart - Aug 10, 2010
- Novel 'patch' to mend broken hearts - Oct 11, 2009
- Scientists fashion first ever 'cyborg' tissues - Aug 27, 2012
- Research may pave way for new regenerative therapies - May 04, 2011
- Engineered stem cells may improve cardiac function after heart attack - Jul 21, 2010
- 'Grafting helps normalise heartbeats' - Aug 06, 2012
- Soon, banks of off-the-shelf body parts for transplants - Jul 14, 2010
- Researchers patch damaged heart with engineered tissue - May 08, 2011
Tags: broken hearts, cardiac tissue, congenital heart defects, electrical field, electrophysiological properties, heart cells, heart muscle, heart tissue, intrinsic ability, massachusetts institute of technology, massachusetts institute of technology mit, mechanical properties, native heart, nature magazine, principal advantages, principal research scientist, rat heart, scaffold, stem cells, whole library