One dose of EPO can limit amount of damage to the heart following attackOctober 9th, 2008 - 5:47 pm ICT by ANI
Washington, Oct 9 (ANI): After a heart attack, two things happen necrosis (normal cell death) and apoptosis (programmed cell death) and both are bad. Now, a group of scientists has found that a single intravenous dose of the hormone erythropoietin (EPO) immediately after the incident can limit the amount of damage to the heart.
The study has been published in the October issue of The Journal of Nuclear Medicine.
One dose of EPO eliminate apoptosis after myocardial infarction (heart attack), the study says.
“The study’’s concept is very novel. We wanted to see if the area of cell death following acute coronary occlusion could be reduced by a single dose of EPO,” said H William. Strauss, M.D., attending physician in the Nuclear Medicine Service at Memorial Sloan Kettering Cancer Center, professor of radiology at Weill Cornell School of Medicine and a co-author of the manuscript.
“Cells deprived of blood quickly begin to die. By administering 99mTc-annexin V, a radiotracer with a high affinity for apoptotic cells, we were able to view the effects of EPO on heart cells immediately following the restriction of blood flow that occurs during MI, the expert said.
In the study, 18 Wistar rats were randomized into two groups. In both groups, arteries were blocked to induce a heart attack; 20 minutes later, they were unblocked.
Immediately afterward, one group (treatment) received an injection of EPO and the other group of saline (non-treatment). Both groups were then injected with 99mTc-annexin V, and their hearts were examined using autoradiography to evaluate the distribution of the radiotracer.
In the treatment group, EPO therapy caused a 2.7-fold reduction of tracer accumulation, indicating a reduction in apoptosis and, therefore, less damage to heart tissue.
The reduction in damage to the heart was also demonstrated by measurement of regional cardiac function, which was significantly better in the EPO-treated group. These findings suggest that EPO may be useful to prevent long-term heart damage and dysfunction after a heart attack.
“Although other drugs to inhibit apoptosis have been studied, none appears nearly as effective as a single dose of EPO,” Strauss said.
EPO is a naturally occurring hormone that promotes the formation of red blood cells in the bone marrow. It was first produced artificially to aid in the treatment of anemia.
Apoptosis is sometimes referred to as “cell suicide,” because the biochemically programmed mechanism triggers damaged cells to self-destruct, albeit in an orderly way.
Researchers have found that cells can die by several pathways, only one of which is apoptosis. Because cell death is central to normal physiology and numerous disease states, research into apoptosis is ongoing in a variety of medical areas, including oncology and cardiology. (ANI)
- Hormone shot boosts prospects of quick recovery from heart attack - Oct 09, 2008
- Blood hormone Epo boosts motivation - Jun 12, 2012
- Sex hormone protects women from cardio risks - Aug 12, 2011
- New approach could reverse liver failure - Aug 06, 2012
- 17-year-old mystery of 'starvation hormone' solved - Dec 27, 2010
- EPO doping 'can cut cerebral malaria related deaths' - Apr 22, 2011
- Pain killers retard recovery from heart attack - Apr 09, 2012
- Viagra, anti-cancer drug combo shrinks tumors in vivo - Sep 28, 2010
- Garlic oil component protects heart - Nov 17, 2011
- Rest can undo damage to heart cells - Apr 02, 2012
- Angina treatment worsens heart attack severity - Nov 03, 2011
- Patients' own stem cells could be used as treatment for their heart disease - Nov 18, 2010
- Kidney gene linked to increased heart failure risk - Jan 18, 2011
- Potential new treatment for blood-related cancers - May 20, 2010
- Platelet-rich plasma 'a promising treatment for heart attacks' - Jan 18, 2011
Tags: annexin v, apoptotic cells, cornell school, coronary occlusion, erythropoietin epo, heart cells, heart tissue, journal of nuclear medicine, kettering cancer center, memorial sloan kettering, memorial sloan kettering cancer center, myocardial infarction, nuclear medicine service, programmed cell death, radiotracer, sloan kettering cancer, sloan kettering cancer center, weill cornell, william strauss, wistar rats