Kids of older dads at higher bipolar riskSeptember 2nd, 2008 - 1:19 pm ICT by ANI
Washington, Sept 2 (ANI): Children born to older fathers are more likely to develop bipolar disorder, common condition sometimes known as manic depression, according to a report in the September issue of Archives of General Psychiatry, one of the JAMA/Archives journals.
Other than a family history of psychotic disorders, few risk factors for bipolar disorder have been identified.
Older paternal age has previously been associated with a higher risk of complex neurodevelopmental disorders, including schizophrenia and autism.
In the latest study, Emma M. Frans, M.Med.Sc., of the Karolinska Institutet, Stockholm, Sweden, and colleagues identified 13,428 patients in Swedish registers with a diagnosis of bipolar disorder.
For each one, they randomly selected from the registers five controls who were the same sex and born the same year but did not have bipolar disorder.
When comparing the two groups, the older an individual’’s father, the more likely he or she was to have bipolar disorder. After adjusting for the age of the mother, participants with fathers older than 29 years had an increased risk.
“After controlling for parity [number of children], maternal age, socioeconomic status and family history of psychotic disorders, the offspring of men 55 years and older were 1.37 times more likely to be diagnosed as having bipolar disorder than the offspring of men aged 20 to 24 years,” the researchers stated.
The offspring of older mothers also had an increased risk, but it was less pronounced than the paternal effect, the authors note. For early-onset bipolar disorder (diagnosed before age 20), the effect of the father’’s age was much stronger and there was no association with the mother’’s age.
“Personality of older fathers has been suggested to explain the association between mental disorders and advancing paternal age,” the researchers stated.
“However, the mental disorders associated with increasing paternal age are under considerable genetic influence, they added.
Therefore, there may be a genetic link between advancing age of the father and bipolar and other disorders in offspring.
The experts said: “As men age, successive germ cell replications occur, and de novo [new, not passed from parent to offspring] mutations accumulate monotonously as a result of DNA copy errors. Women are born with their full supply of eggs that have gone through only 23 replications, a number that does not change as they age.
Therefore, DNA copy errors should not increase in number with maternal age. Consistent with this notion, we found smaller effects of increased maternal age on the risk of bipolar disorder in the offspring.” (ANI)
- Bipolar disorder more likely in children of older fathers - Sep 02, 2008
- Offspring of older fathers may live longer - Jun 12, 2012
- Kids of older women 'vulnerable to effects of prenatal alcohol exposure' - Jul 21, 2010
- Fathering at 50? Your kids may be autists - Sep 02, 2011
- Scientists identify genetic link to suicide attempts - Mar 29, 2011
- Does dad's stress affect his kids? - Sep 01, 2011
- Psychotic-like symptoms linked to poor outcomes in depression patients - Dec 07, 2010
- Blame your mum for your high BP - Apr 01, 2011
- Trauma victims can develop schizophrenia - Apr 20, 2012
- Puffing could expose your kid to leukaemia - Feb 10, 2012
- Alzheimer's risk increases with maternal inheritance - Nov 16, 2010
- 'Kids of 40-plus moms are smarter' - May 22, 2012
- Older mothers more prone to have children with autism - Feb 09, 2010
- Babies born in spring 'more likely to develop anorexia nervosa' - Apr 28, 2011
- Baby's genome decoded from mom's blood, pop's saliva - Jun 07, 2012
Tags: archives of general psychiatry, diagnosis of bipolar disorder, karolinska institutet stockholm, manic depression, maternal age, neurodevelopmental disorders, older mothers, psychotic disorders, september issue, stockholm sweden