Key contributor to Alzheimer’’s disease process identifiedNovember 15th, 2008 - 3:41 pm ICT by ANI
Washington, Nov 15 (ANI): Researchers from Louisiana State University, New Orleans claim to have identified a key contributor in the development of Alzheimer’’s disease.
They revealed that a fragment of ribonucleic acid (RNA), once thought to be no more than a by-product, plays a crucial role in regulating inflammation and the development of Alzheimer’’s disease.
The tiny piece of RNA, or microRNA, called miRNA-146a was found in increased amounts in stressed human brain cells and Alzheimer’’s disease
Lead researcher Walter J. Lukiw, PhD, Associate Professor of Neuroscience and Ophthalmology at LSU Health Sciences Centre showed that MiRNA-146a targets the messenger RNA of an important anti-inflammatory regulator called complement factor H (CFH).
Testing both control cells and Alzheimer’’s disease-affected tissues, they found that miRNA-164a appears to reduce the amount and bioavailability of CFH, promoting the inflammation of brain cells and contributing to the development of Alzheimer’’s disease.
“The goal of these neuroscience research studies is to further our understanding of the molecular biology and genetic mechanisms associated with Alzheimer’’s Disease and to advance the design of therapeutic strategies to counteract this common and tragic neurological disorder,” said Dr. Lukiw.
The most common form of dementia, Alzheimer’’s Disease is a fatal, age-related neurodegenerative disorder characterized clinically by the progressive erosion of cognition and memory.
The study appears in The Journal of Biological Chemistry. (ANI)
- Micro-RNA that regulates insulin in obesity identified - Apr 01, 2011
- MicroRNAs could increase amputation risk in diabetics - Jan 13, 2011
- Scientists convert skin cells to stem cells more effieciently - Feb 03, 2011
- Key step in body's ability to make red blood cells found - Aug 01, 2010
- Autism effects may be reversible - Apr 24, 2010
- Scientist converts skin cells into brain cells - Jul 29, 2011
- New molecule may save brain cells from neurodegeneration, stroke - Jan 19, 2011
- Boffins identify 'gas pedal', 'brake' for uncontrolled cell growth - Aug 02, 2010
- Gene variant role in Parkinson's discovered - Aug 01, 2010
- How ovarian cancer resists chemotherapy - Mar 03, 2011
- Gene makes ovarian cancer resistant to chemotherapy - Mar 03, 2011
- New discovery could shrink dengue-spreading mosquito population - Dec 03, 2010
- Scientists uncover clues to cancer development in AIDS patients - Jun 18, 2009
- Function of novel molecule that underlies human deafness revealed - Jan 22, 2011
- Previously unknown natural mechanism behind cocaine addiction uncovered - Jul 08, 2010
Tags: bioavailability, cfh, cognition, complement factor, control cells, dementia, genetic mechanisms, health sciences centre, human brain cells, journal of biological chemistry, louisiana state university, lsu health sciences, messenger rna, microrna, molecular biology, neurological disorder, neuroscience research, ribonucleic acid, therapeutic strategies, tiny piece