Hepatitis B virus triggers cell ’suicide’ in chronically infected patientsApril 9th, 2008 - 4:25 pm ICT by admin
Washington, Apr 9 (ANI): Researches at the University College London have shed light on why some people can fight the Hepatitis B virus (HBV) off successfully while some cant, by finding that a group of cells important in controlling the disease are triggered to commit suicide in patients who are chronically infected.
Dr Mala Maini and colleagues found that Hepatitis B virus (HBV) triggers a group of cells, called T cells, to commit suicide in patients who are chronically infected.
The researchers say that their findings may have future implications for developing therapies or vaccines that boost the bodys ability to manage this infection.
For the study, the researchers examined thousands of genes in T cells, critical players of the immune system required for control of HBV and found that T cells from patients who were chronically infected were triggered to commit suicide.
This discovery can act as an important factor in determining why these patients immune systems cannot fight the infection, the team said.
Hepatitis B virus (HBV) is one of the most common viruses in the world and over 350 million people have long-term infection with HBV, which may lead to liver cirrhosis, liver failure or liver cancer.
We used microarray gene chips to screen more than 5,000 genes in T cells from both recovered and chronically infected Hepatitis B patients. This led to the discovery that, instead of successfully reacting to the virus, the T cells in the latter group were triggered to commit suicide by one of the cells own death-inducing proteins, called Bim. We are now looking into the fine mechanism driving this outcome, said Maini.
If we can develop safe ways of blocking the suicidal tendency of the T cells, we may be able to prolong their survival, so they can do a better job of controlling Hepatitis B infection, added the papers first author, Ross Lopes.
The findings of this study are published in the Journal of Clinical Investigation. (ANI)
- New vaccine technology shows promise against hepatitis C virus - Feb 24, 2011
- Boosting body's immune system may hold key to HIV cure - Feb 04, 2011
- Hepatitis could kill 5 mn in Southeast Asia: WHO - Jul 24, 2012
- Shark liver compound could treat dengue, hepatitis - Sep 20, 2011
- 'Pep talk' can revive exhausted immune cells: Study - Dec 14, 2011
- Scientists show how infection fighting cells form - Jul 10, 2012
- Why hepatitis B hits men harder than women - Nov 19, 2009
- Fancy a tattoo? Beware of hepatitis virus (July 28 is World Hepatitis Day) - Jul 28, 2011
- Beware! You may be more vulnerable to hepatitis than you think (July 28 is World Hepatitis Day) - Jul 27, 2012
- 'Pregnant women more vulnerable to Hepatitis E-induced liver failure' (July 28 is World Hepatitis Day) - Jul 26, 2012
- Coffee can cure hepatitis C - Jun 08, 2011
- '40 million infected with Hepatitis B in India' - Jul 26, 2011
- Anesthesia misuse could lead to hepatitis virus transmission - Jul 23, 2010
- Hepatitis B targets men more viciously than women - Nov 19, 2009
- 80 percent of Jakarta adults had Hepatitis A - Nov 11, 2011
Tags: author ross, cell suicide, cirrhosis liver, critical players, gene chips, genes, hepatitis, hepatitis b, hepatitis b virus, immune system, immune systems, liver cancer, liver failure, maini, proteins, researches, suicidal tendency, t cells, university college london, vaccines