Dancing hair cells are key to humans acute hearing: StudyMay 8th, 2008 - 1:45 pm ICT by admin
Washington, May 8 (ANI): St. Jude Children’s Research Hospital investigators in their new study have shown how dancing hair cells contribute to amplifying sounds in the inner ear, a finding that could explain how hearing loss can result from genetic mutation or overdose of drugs
The researchers have found that an electrically powered amplification mechanism in the cochlea of the ear is critical to the acute hearing of humans and other mammals.
The findings will enable better understanding of how hearing loss can result from malfunction of this amplification machinery due to genetic mutation or overdose of drugs such as aspirin.
Sound entering the cochlea is detected by the vibration of tiny, hair-like cilia that extend from cochlear hair cells. While the cochleas inner hair cells are only passive detectors, the so-called outer hair cells amplify the sound signal as it transforms into an electrical signal that travels to the brains auditory center.
Without such amplification, hearing would be far less sensitive, since sound waves entering the cochlea are severely diminished as they pass through the inner ear fluid.
In the research, the team has sought to establish the mechanism by which outer hair cells produce such amplification.
Specifically, they wanted to distinguish between two amplification theoriescalled stereociliary motility and somatic motilitythat have resulted from previous studies of the auditory machinery.
The stereociliary theory holds that amplification is produced by intricate vibrations of the bundles of cilia extending from the outer hair cells.
The somatic motility theory proposes that the sound signal is amplified by an amplifier protein, called prestin, embedded in the hair cell membrane.
Prestin is powered by voltages within the membrane that are produced by mechanical sound vibrations.
This motility is also called dancing because when you electrically stimulate an outer hair cell with a sound, the cell body spontaneously elongates and contracts along with the sound. It is very dramatic to see these hair cells dance with the sound, said Jian Zuo, Ph.D., associate member of the St. Jude Department of Development Neurobiology.
In the research, the scientists genetically altered mice to have only subtle alterations in the prestin protein. These alterations only compromised prestins function as an amplifier but did not otherwise affect the outer hair cell structure or function, the researchers analysis showed.
We found that these mice showed exactly the same kinds of hearing deficiency as the previous knockout mice. Therefore, we believe that these experiments eliminate criticism of our earlier experiments with the knockout mice, Zuo said.
The new experiments, Zuo said, thus firmly establish that the dancing somatic motility of the outer hair cells is critical to cochlear amplification.
However, he noted, With this study we still cannot really exclude stereociliary motility from contributing to cochlear amplification, because eliminating somatic motility also reduces ciliary motility. So, it is not possible to totally isolate either form of motility. In fact, we hypothesize that the two mechanisms might work together in different aspects of amplification.
The study is published in the May 8 issue of the journal Neuron. (ANI)
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