Bone marrow transplant may offer HIV cureNovember 13th, 2008 - 1:01 pm ICT by ANI
New Delhi, Nov 13 (ANI): Researchers from Berlin’’s Charite hospital were successfully able to ward off HIV virus from a patients body with the help of bone marrow transplantation.
According to the doctors, bone marrow transplants are generally used to fight leukaemia, however, during the present study the researchers found that the procedure can also prove effective against HIV virus.
The research was conducted by Dr. Gero Huetter over a 42-year-old American man from Berlin who had been infected with the AIDS virus for more than a decade.
However, after the transplantation of genetically selected bone marrow, he no longer showed signs of carrying the virus, reports China Daily.
But Dr. Andrew Badley, director of the HIV and immunology research lab at the Mayo Clinic in Rochester, Minn, suggests, a lot more scrutiny from a lot of different biological samples would be required to say it’’s not present.
Before the transplant, the patient was asked to take powerful drugs and radiation to kill off his own infected bone marrow cells and disable his immune system.
He also stopped the use of important drugs to treat AIDS, anticipating that the new, mutated cells would ward off virus on their own
Huetter revealed that some people carry a genetic mutation called Delta 32 that apparently makes them resistant to HIV infection.
If the mutation is inherited from both parents, it prevents HIV from attaching itself to cells by blocking CCR5, a receptor critical for the spread of AIDS virus.
“It helps prove the concept that if somehow you can block the expression of CCR5, maybe by gene therapy, you might be able to inhibit the ability of the virus to replicate,” said Fauci. (ANI)
- German doc miraculously cures AIDS patient - Nov 13, 2008
- US scientists create HIV-resistant cells - Jul 03, 2010
- 'AIDS cure' good for only one percent of patients: experts - Nov 24, 2008
- Genetic treatment to thwart HIV shows promise - Mar 04, 2011
- How HIV escapes treatment - Mar 08, 2010
- Triple-punch gene therapy offers hope to AIDS patients - Jun 17, 2010
- New 'poison' discovery could pave way for leukaemia therapy - Dec 04, 2010
- 'Miracle' blood transplant 'cures American man of HIV' - Dec 15, 2010
- Bone marrow can harbour HIV-infected cells - Mar 09, 2010
- Gene-based stem cell therapy may help treat HIV-infected individuals - Feb 26, 2010
- Nerve cells naturally protect themselves against HIV - Jul 29, 2009
- Protein knocks out HIV by starving it of raw materials - Feb 13, 2012
- Pak businessman is Delhi's first marrow transplant case from unrelated donor - Sep 17, 2012
- Cancer drug successfully purges hidden HIV virus - Mar 09, 2012
- Measles virus plays key role in Paget's disease of bone - Jan 15, 2011
Tags: aids virus, american man, badley, biological samples, bone marrow cells, bone marrow transplant, bone marrow transplantation, bone marrow transplants, charite, china daily, delta 32, dr andrew, dr gero, gene therapy, genetic mutation, hiv infection, hiv virus, immunology research, mayo clinic, rochester minn