Boffins turn to pigs to find cystic fibrosis treatmentSeptember 26th, 2008 - 5:41 pm ICT by ANI
Washington, Sept 26 (ANI): In a breakthrough study, a University of Missouri researcher is producing pigs born with cystic fibrosis (CF) that mimic the exact symptoms of human CF, and may help in further studying the deadly lung disease.
Cystic Fibrosis continues to be a lethal disease for humans despite the identification of the problematic gene two decades ago. Many humans born with CF the most common genetic disease in Caucasians - often die because of a lung disease developed later.
Till date, scientists have been not been able to develop an animal model that develops the fatal lung disease.
But now, the researchers are hopeful that these pigs will continue to mimic the human symptoms so the fatal lung disease can be studied and ultimately treated.
“Right now, if you want to do experiments to find treatments or therapies for the lung disease that is fatal for people with CF, you would have to experiment on kids that have CF,” said Randy Prather, distinguished professor of reproductive biotechnology in the MU College of Agriculture, Food and Natural Resources.
He added: “When the genetic mutation is introduced into mice, they do not display the symptoms of CF. That’’s why these new swine models are so important. We have been able to get them through the initial stages of the disease, which they display just like humans, and now we are just waiting for them to grow and potentially develop the lung disease so we can start experimenting in ways that have never been possible.”
In a collaborative effort, Prather created the genetic defect in pigs, while a team led by Michael Welsh from the Howard Hughes Medical Institute at the University of Iowa, made genetic modifications in pig cells.
Prather’’s group then generated the genetically modified pigs from the cells using a process known as nuclear transfer.
The pigs called founder animals - that were produced carried only one copy of the mutated gene. Prather bred the pigs naturally and now many piglets have been born with CF.
Once a liter was born, the piglets were immediately flown to Iowa where physicians who perform the corrective surgery on human newborns with CF did the same for the pigs.
In the meantime, researchers performed analysis during the transit to determine which piglets have the mutations
“So far, all the mutations in the pigs have exactly mimicked the problems in humans born with CF. The whole cellular physiology of the pig is similar to humans. That’’s why having this break- through model is so exciting for the potential it has to move research on cystic fibrosis forward,” said Prather.
The research is published in the journal Science. (ANI)
- Growth defects in patients with cystic fibrosis 'may start before birth' - Nov 10, 2010
- Boffins come closer to understanding how cystic fibrosis causes lung disease - Apr 29, 2010
- Crosstalk between ion channels leads to new therapeutic strategy - Sep 20, 2010
- Drug targets defective protein that causes cystic fibrosis - Nov 18, 2010
- Genetically modified 'sick pigs' created to cure human diseases - Jun 17, 2010
- Scientists turn benign virus into good gene therapy carrier for cystic fibrosis - Feb 17, 2009
- Infliximab treatment effective for cystic fibrosis and Crohn's disease - Apr 20, 2010
- Scientists one step closer to a drug treatment for cystic fibrosis - Oct 13, 2010
- GM cloned piglets in China 'bring transplant hope for humans' - Mar 23, 2011
- Protein involved in cystic fibrosis linked to chronic lung diseases - Dec 30, 2010
- Novel drug may benefit cystic fibrosis patients - Dec 18, 2010
- Fatal lung vascular disease 'caused by silencing of genes' - Jun 08, 2010
- Human lungs can sweep out intruders - Aug 26, 2012
- DIY DNA tests tell couples about their unborn baby's genetic disease risk - Mar 27, 2011
- Inhalation therapy proves effective against cystic fibrosis - Feb 06, 2009
Tags: agriculture food, breakthrough study, college of agriculture, common genetic disease, cystic fibrosis, deadly lung disease, fatal lung disease, genetic defect, genetic modifications, genetic mutation, howard hughes medical, howard hughes medical institute, hughes medical institute, lethal disease, michael welsh, mu college, nuclear transfer, pig cells, prather, reproductive biotechnology