Boffins confirm long-term benefits of morphine treatment in infantsNovember 4th, 2008 - 12:57 pm ICT by ANI
Washington, November 4 (ANI): Administration of preemptive morphine prior to a surgery in infancy tends to block the long-term negative consequences of pain in adult rodents, confirms a new study.
Researchers at Georgia State University have been the first to prove that infants who were not administered pre-emptive morphine before a painful procedure will need more morphine in adulthood to modulate their pain.
The study, which has been published online in Pediatric Research, had divided a group of rat pups into two, with one group receiving an injection of morphine sulfate on the day of birth while the other received a saline injection prior to inducing inflammation.
While the former group of rodents behaved normally after getting identical procedures during a 60-day period, the latter showed significant increases in pain sensitivity and were resistant to the pain relieving effects of morphine in adulthood.
According to Anne Z. Murphy, Ph.D., a GSU Professor of Neuroscience and member of the Center for Behavioral Neuroscience, and graduate student Jamie LaPrairie, the results confirmed the long-term behavioural benefits.
Murphy said: These results suggest that there are long-term benefits of providing all newborns with some sort of pain relieving medicine prior to the initiation of an invasive procedure.” (ANI)
Tags: adulthood, behavioral neuroscience, day of birth, effects of morphine, georgia state university, graduate student, infancy, inflammation, initiation, invasive procedure, morphine, morphine sulfate, negative consequences, newborns, pain sensitivity, pediatric research, rat pups, rodents, saline injection, study researchers