Scientists decode TB enzyme, open way to new drugsMarch 28th, 2009 - 4:55 pm ICT by IANS
Washington, March 28 (IANS) Scientists have decoded the unique structure and mechanism of a tuberculosis enzyme, paving the way for development of new drugs to combat active and latent tuberculosis infections.
Barbara Gerratana, assistant chemistry and biochemistry professor in Maryland University College of Chemical and Life Sciences, led the research team, which included her graduate student Melissa Resto and assistant professor Nicole LaRonde-LeBlanc.
“The NAD plus synthetase enzyme that our study describes is absolutely essential for the survival of tuberculosis bacteria and an important drug target. We can now use the information we have about its structure and mechanism to develop inhibitors for this enzyme,” Gerratana explained.
The development of new TB drugs has become urgent, as strains of TB resistant to all major anti-TB drugs have emerged worldwide. World Health Organisation estimates that one-third of the world’s population carries latent TB and that 10 percent will eventually develop the disease, said a Maryland release.
The study was published in the March issue of Nature Structural and Molecular Biology.
- TB enzyme's discovery brings new drug therapies closer to reality - Mar 28, 2009
- Should tuberculosis (TB)-preventive therapy (IPT) be given to all? - Aug 02, 2010
- Disrupting key structure in TB bacterium could aid in new drug design - May 12, 2010
- New findings on drug tolerance could help cure TB faster - Mar 04, 2011
- Central team to probe drug resistant TB cases in Mumbai - Jan 17, 2012
- TB-drugome may pave way for anti-TB drug discovery - Nov 09, 2010
- Scientists get glimpse of how 'code' of life may have emerged - Mar 24, 2011
- New test can quickly distinguish infection from tuberculosis disease - Apr 02, 2011
- Tuberculosis enzyme responsible for lung destruction identified - Apr 26, 2011
- Addressing poverty in TB control: The Thailand experience - Nov 04, 2010
- Priority is to up collaborative TB-HIV activities - Jul 19, 2010
- New weapon to fight malaria, disease-causing bacteria developed - Feb 16, 2010
- 'Time to scale up work on TB control' - Jan 24, 2012
- Berlin 2010: TB, HIV and Lung Health: From research and innovation to solutions - Nov 02, 2010
- A childhood free from tuberculosis (TB) - Jul 17, 2010
Tags: 10 percent, assistant professor, drug target, graduate student, laronde, latent tb, latent tuberculosis, life sciences, maryland university college, melissa, nature structural and molecular biology, new drugs, paving the way, resto, strains, tb drugs, tuberculosis, tuberculosis bacteria, tuberculosis infections, world health organisation