Red wine, fruits and veggies reduce cancer, heart disease risk depending on dose

November 14th, 2007 - 8:10 am ICT by admin  
In their study, published in the FASEB Journal, French scientists have laid the groundwork for safe, new cancer therapies by describing how high and low doses of polyphenols, chemicals commonly found in red wine, fruits, vegetables, and green tea, have different effects.

Most remarkably, they found that very high doses of antioxidant polyphenols shut down and prevent cancerous tumours by cutting off the formation of new blood vessels needed for tumour growth.

At relatively low doses, the French researchers found that the same polyphenols play a beneficial role for those with diseased hearts and

circulatory systems by facilitating blood vessel growth.

The amount of polyphenols necessary for this effect was found to be the equivalent of only one glass of red wine per day or simply sticking to a healthy diet of fruits and vegetables containing polyphenols. This diet is known as the “Mediterranean Diet.”

According to the authors, their study also adds to a growing body of research showing dose-dependent relationships for many types of commonly used compounds.

“When it comes to finding treatments for complex diseases, the answers are sometimes right there waiting to be discovered in unexpected places like the produce aisles and wine racks of the nearest store,” said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal.

“But it takes modern science to isolate the pure compound, test it in the lab, and to go on from there to find new agents to fight disease,” he added.

The authors said that the amount of polyphenols necessary to obtain an anti-cancer effect is the equivalent of drinking about a bottle of red wine each day.

This amount of daily alcohol consumption obviously is unhealthy, but the research suggests that polyphenols extracted from plants or red wine could be converted into a pill that is highly likely to be safe. Such a pill also would be relatively easy and inexpensive to create and deliver.

“The use of plant polyphenols as therapeutic tools presents important advantages, because they have a good safety profile, a low cost and they can be obtained everywhere on the planet,” said Daniel Henrion, senior author of the study. (ANI)

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