New study of bone structure raises questions for osteoporosis treatmentNovember 14th, 2007 - 2:23 am ICT by admin
He revealed that the study has shown that the characteristic toughness and stiffness of bone is predominantly due to the presence of specialized sugars, not proteins, as was earlier thought.
During the study, the researchers studied mineralization in horse bones using an analysis tool called nuclear magnetic resonance (NMR).
They observed that sugars, particularly proteoglycans (PGs) and glycosaminoglycans (GAGs), appeared to play a role which is as important as proteins in controlling bone mineralization, the process by which newly-formed bone is hardened with minerals such as calcium phosphate.
“We believe our findings will alter some fundamental preconceptions of bone biology. On a practical level they unveil novel targets for drug discovery for bone and joint diseases, new biomarkers for diagnosis, and new strategies for developing synthetic materials that could be used in orthopaedics,” Dr. Reid said.
“They may also strengthen the rationale for the current popularity of over-the-counter joint and bone pain remedies such as glucosamine and chondroitin, which are based on GAG sugar molecules,” he added. (ANI)
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Tags: bone biology, bone disorders, bone mineralization, bone pain, bone structure, calcium phosphate, david reid, dr reid, findings, glucosamine and chondroitin, glycosaminoglycans, horse bones, novel targets, nuclear magnetic resonance, osteoporosis treatment, pgs, proteins, proteoglycans, sugar molecules, sugars