New molecular target to improve chemotherapy efficacy identifiedNovember 14th, 2007 - 8:16 am ICT by admin
SphK2 is an enzyme that forms the potent lipid mediator sphingosine-1-phosphate in the death of cancer cells mediated by the chemotherapeutic drug, doxorubicin.
Doxorubicin is able to kill cancer cells by working with p53, one of the most protective anti-cancer proteins in the human body.
However, doxorubicin also relies on p53- independent mechanisms to induce death in colon and breast cancer cells.
“Understanding how doxorubicin kills in a p53-independent manner is a major goal of cancer researchers because most cancer cells have mutated p53,” Spiegel said.
Spiegel said that the study established SphK2 important for p53-independent induction of expression of p21, a cyclin-dependent kinase inhibitor.
The p21 regulates the cell cycle, and apoptosis or programmed cell suicide, mediated by doxorubicin. Human colon and breast cancer cells were killed more efficiently by doxorubicin when SphK2 was removed from the cells.
“Therefore, the findings suggest that SphK2 influences the balance between cytostasis, and apoptosis of human cancer cells,” Spiegel said.
Cytostasis refers to the stoppage of cellular growth and multiplication.
Spiegel said that cell death was induced by doxorubicin and decreased p21.
The study is published in the journal Cancer Research. (ANI)
- How red wine and green tea can prevent prostate cancer growth - Jun 10, 2010
- Protein that makes tumor cells in breast cancer resistant to treatments - Dec 15, 2010
- Cell killer enzyme could help cancer treatment - Mar 06, 2011
- Latin brew bumps off colon cancer cells - Jan 24, 2012
- New way to kill cancer cells discovered - Sep 18, 2011
- Potential new treatment for blood-related cancers - May 20, 2010
- Secrets of common virus that can cause cancer decoded - Dec 16, 2010
- Protein that contributes to ulcerative colitis revealed - Apr 02, 2011
- Trio of drugs may help fight 'triple negative' breast cancer - Dec 11, 2010
- Small molecules 'could block cell proliferation in cancerous human tumor' - Apr 14, 2011
- Overabundance of protein promotes growth of breast cancer stem cells - Feb 16, 2011
- Novel peptide 'kills' cancer cells more effective than current therapies - Jan 23, 2011
- New drug shows promise against platinum resistant ovarian cancer - Oct 10, 2010
- Viagra, anti-cancer drug combo shrinks tumors in vivo - Sep 28, 2010
- How broccoli fights cancer - Jan 27, 2011
Tags: apoptosis, breast cancer cells, cancer cell biology, cancer proteins, cell biology program, cell suicide, cellular growth, cyclin dependent kinase, department of biochemistry and molecular biology, doxorubicin, human cancer cells, human colon, independent mechanisms, journal cancer, molecular target, p21, p53, sphingosine, spiegel, vcu