How environmental stress causes cancer revealedNovember 14th, 2007 - 8:33 am ICT by admin
The researchers found that stress-inducing agents, such as oxidative stress, recruited a protein called SENP1 that removed a regulator called SUMO1 away from the enzyme SIRT1 so that its activity level drops.
SIRT1, found throughout the body, is a regulator of protein function through a process called acetylation.
Yang said that increased SIRT1 activity, which was routinely present in cancer, even made cancer cells more resistant to anticancer drugs such as chemotherapy.
Yang added that the complication was decreasing programmed cell death, or apoptosis increased longevity.
“Whether apoptosis is good or bad depends on the circumstances. But it’s good for cancer therapy,” Yang said.
The team said that the study described as to how stress caused desumoylation and sumoylation of SIRT1 and ultimately caused cancer.
“This paper describes how stress causes desumoylation and sumoylation of SIRT1 and ultimately cancer,” the researchers said.
Bhalla said that stress-inducing agents produced the association of the enzyme, SIRT-1, with the desumoylating enzyme, SENP1, so that cells became more resistant to stress-induced apoptosis.
“Stress-inducing agents produce the association of this enzyme, SIRT-1, with the desumoylating enzyme, SENP1, so cells become more resistant to stress-induced apoptosis,” Bhalla said.
“Once SIRT1 is desumoylated, it’s less active and you want its activity. When SIRT1 is less active, p53, a tumour suppressor gene that also causes apoptosis, becomes more active,” he added.
Yang said that the finding about the relationship between stress and cancer opened the door for treatments that increased SENP1 activity, making it easier for cells that were becoming cancerous, to die.
“This is one of the things that makes cancer cells so durable, one way they survive so well. We want to see if we can block that process and make cells die,” he said.
The study is published in Nature Cell Biology. (ANI)
- Key step for regulating embryonic development discovered - Apr 23, 2010
- Stress before cancer therapy may sabotage treatment - Sep 22, 2010
- Aging-related protein holds breast cancer clues - Jan 28, 2011
- Novel peptide 'kills' cancer cells more effective than current therapies - Jan 23, 2011
- Protein that protects cancer cells from chemo, radiation therapy found - Mar 25, 2011
- Potential therapeutic target for breast cancer identified - Apr 06, 2011
- Protein that makes tumor cells in breast cancer resistant to treatments - Dec 15, 2010
- New way to kill cancer cells discovered - Sep 18, 2011
- Compound boosts cancer-killing properties of agent in trials - Jun 10, 2010
- New hope for cancer cure - Jul 08, 2011
- 'Chaperone' enzyme could help cells tolerate cancer-causing DNA damage - Jan 19, 2011
- Proteins' absence causes diabetes, rheumatoid arthritis - Sep 10, 2012
- Scientists provide genetic evidence that antioxidants can help treat cancer - Feb 16, 2011
- How stressed cells boost production of key blood clotting factor - Feb 05, 2011
- Key protein in energy regulation identified - Mar 04, 2010
Tags: acetylation, anticancer drugs, apoptosis, cancer cells, cancer centre, cancer therapy, oxidative stress, p53, programmed cell death, protein function, sirt, sirt1, stress causes, suppressor gene, this paper describes, tumour suppressor, university of south florida