Faster body metabolism renders TB drugs ineffectiveJanuary 4th, 2012 - 3:03 pm ICT by IANS
Washington, Jan 4 (IANS) Tuberculosis (TB) which becomes resistent to multi-drugs is not caused by irregular doses, as is widely believed, but by speedy drug metabolism, according to a US study.
The body sees drugs as foreign chemicals and tries to rid itself of them, said Tawanda Gumbo, associate professor of internal medicine at the University of Texas Southwestern, who led the study.
A population of individuals with a genetic trait that speeds the metabolic process has been found in one area of South Africa that has a high rate of multidrug-resistant TB.
“Tuberculosis is a common ailment, accounting for up to three percent of all deaths in many countries,” said Gumbo.
“Although effective therapy exists, there are still cases of treatment failure, and drug resistance remains a threat,” added Gumbo.
The results seem to challenge the current approach endorsed by the World Health Organization that relies on directly observed therapy-short-course strategy (DOTS).
TB that responds to medication is treated with a cocktail of drugs under the supervision of health care workers.
“Every TB patient is supposed to be watched as they swallow their pills in order to increase adherence and decrease emergence of drug resistance,” said Gumbo.
In fact, using computer simulations based on 10,000 TB patients in Cape Town, South Africa, researchers discovered that one percent of all TB patients with perfect adherence to dosage still developed drug resistance because they cleared the drugs from their bodies more quickly.
- 'Time to scale up work on TB control' - Jan 24, 2012
- Standard re-treatment regimen for TB 'failing' in developing world - Mar 16, 2011
- Awareness programmes mark World Tuberculosis Day in Delhi - Mar 24, 2011
- WHO calls for dealing with multi-drug resistant microbes - Apr 07, 2011
- New test top diagnoseTB proves effective, convenient - Sep 02, 2010
- Berlin 2010: TB, HIV and Lung Health: From research and innovation to solutions - Nov 02, 2010
- New findings on drug tolerance could help cure TB faster - Mar 04, 2011
- No drug-resistant TB case in India: Expert team - Jan 20, 2012
- Higher drug doses needed to fight TB, say boffins - Jul 31, 2009
- 'Urgent measures needed to control drug resistant TB' - Mar 23, 2012
- Drug resistant TB? No way, says government - Jan 20, 2012
- Study sheds light on metabolic vulnerability in TB and potential drug target - May 11, 2010
- TB causing half million annual deaths in South-East Asia: WHO - Mar 22, 2012
- Health ministry to tweak TB campaign - Mar 23, 2011
- Central team to probe drug resistant TB cases in Mumbai - Jan 17, 2012
Tags: area of south africa, body metabolism, cape town south africa, computer simulations, course strategy, dots tb, drug metabolism, drug resistance, effective therapy, genetic trait, health care workers, metabolic process, multi drugs, resistant tb, tb drugs, tb patient, tb patients, treatment failure, tuberculosis tb, world health organization