Enzyme may help increase tumours’ sensitivity to radiation therapyNovember 14th, 2007 - 8:24 am ICT by admin
In the study, the researchers showed that MOF is an essential factor for tumour development.
MOF adds a tag ‘a special chemical group’ to the spools that hold the long strands of DNA in the chromosomes.
The spools, made of proteins called histones, pack the genetic material into a more condensed form.
By adding a tag at a precise location on one kind of histone, MOF helps relax the tight packing of genes and thereby influences how active the genes are.
Although many enzymes are involved in controlling chromosome structure to maintain cells’ genetic machinery, MOF is so essential that without it cells inevitably die.
The team said that it might be possible to manipulate the enzyme to make tumours more sensitive to radiation therapy.
“We think that if we can deplete MOF in tumor cells, but not in healthy cells, we will gain a therapeutic advantage,” Pandita said.
“If we affect MOF in tumor cells, they will be weakened and unable to recover after radiation exposure,” he added.
The study also confirmed that cells with less MOF were more sensitive to radiation exposure.
The study will be published in the journal Molecular and Cellular Biology. (ANI)
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Tags: barnes jewish hospital, chemical group, chromosome structure, dna, genes, genetic machinery, histones, mof, radiation exposure, radiation therapy, school of medicine, siteman cancer center, spools, tumor cells, washington university school of medicine