Discovery to help minimise drugs’ side-effectsDecember 21st, 2011 - 2:06 pm ICT by IANS
Washington, Dec 21 (IANS) A missing link between the body’s bio-clock and sugar metabolism may help avoid the serious side-effects of drugs used in treating asthma, allergies and arthritis, reveals a study.
Scientists discovered that proteins controlling the body’s bio-rhythms, known as cryptochromes, also interact with metabolic switches that are targeted by certain anti-inflammatory drugs.
The finding suggests that side-effects of current drugs might be avoided by considering patients’ bio rhythms when giving drugs, or by developing new drugs that target cryptochromes, the journal Nature reported.
“We knew that our sleep and wake cycle are tied to when our bodies process nutrients, but how this happened at the genetic and molecular level was a complete mystery,” said Ronald M. Evans, professor in Salk’s Gene Expression Lab, who led the research team.
“Now we’ve found the link between these two important systems, which could serve as a model for how other cellular processes are linked and could hold promise for better therapies,” said Evans, according to a university statement.
“Disrupting the normal day-night cycle of activity may prevent a person’s biological clock from synchronizing correctly with their daily patterns of nutrient metabolism, as a result, the body might not store and process sugar normally, leading to metabolic disease,” Evans said.
More broadly, the study may help explain the connection between sleep and nutrient metabolism in our bodies, including why people with jobs that require night work or erratic hours are at higher risk for obesity and diabetes, he added.
- Scientists discover better drugs for sleep problems - Apr 09, 2012
- Upsetting bio-clocks causes brain degeneration, early death - Jan 11, 2012
- A rhythm awry means rolls of fat - Aug 30, 2012
- Tweaking plants' bio-clock can revolutionise food output - Sep 04, 2011
- Liver's role vital in regulating body clock - May 04, 2012
- Indian-American identifies 'wake-up' gene - Sep 30, 2011
- Link between light signal and circadian rhythms discovered - Dec 30, 2010
- New mechanism regulating body's 24-hour clock identified - Nov 12, 2010
- Biochemical to treat diabetes discovered - Jul 16, 2012
- Clock gene prepares plants for spring bloom - Mar 12, 2012
- Childhood obesity could erode fertility later - Aug 01, 2012
- Mechanism that controls 24-hour clock of all forms of life discovered - Jan 27, 2011
- Our body clocks determine how much fat we burn - Nov 16, 2010
- Circadian clock genes control appetite, consumption in fruit flies - Dec 07, 2009
- Gut bacteria can control functions of organs: Study - Mar 01, 2011
Tags: anti inflammatory drugs, asthma allergies, bio rhythms, biological clock, cellular processes, effects of drugs, expression lab, gene expression, journal nature, metabolic disease, missing link, new drugs, nutrient metabolism, nutrients, proteins, salk, side effects of drugs, sugar metabolism, synchronizing, target