Carbon monoxide may actually save lives and boost health in futureNovember 14th, 2007 - 2:19 am ICT by admin
The researchers say that the gas is lethal when inhaled in large amounts, but administering it in small doses to patients can reduce inflammation, widen their blood vessels, increase blood flow, and prevent unwanted blood clotting.
They said that small doses of carbon monoxide could even suppress the activity of cells and macrophages which attack transplanted organs.
Researchers have for long known that CO is produced in the body as part of its own natural defensive systems, and that delivering the right dose of the gas to the patient may provide him with several advantages.
However, the big question before them was how to administer the right dose of CO to patients safely, as the conventional method of gas inhalation could expose patients to high doses.
The new CO-releasing molecules (CO-RMs) have been developed in partnership with Dr Roberto Motterlini at Northwick Park Institute for Medical Research (NPIMR) and with funding from the Engineering and Physical Sciences Research Council (EPSRC).
“The molecules dissolve in water, so they can be made available in an easy-to-ingest, liquid form that quickly passes into the bloodstream,” says Professor Brian Mann, from the University’s Department of Chemistry, who led the research.
“As well as making it simple to control how much CO is introduced into a patient’s body, it will be possible to refine the design of the molecules so that they target a particular place while leaving the rest of the body unaffected,” he added.
The CO-RMs consist of carbonyls of metals such as ruthenium, iron, and manganese which are routinely used in clinical treatments. They can be designed to release CO over a period of between 30 minutes and several hours, depending upon the treatment required for a particular medical condition.
The researchers said that the new molecules could help reduce the time that patients need to spend in hospital, besides enabling some patients to avoid going into hospital in the first place.
“This project provides an excellent example of how non-biological sciences like chemistry can underpin important advances in healthcare,” said Professor Mann.
Clinical trials with the new molecules are expected to begin in around two years. (ANI)
- How humans avoid carbon monoxide poisoning - Sep 21, 2011
- Vitamin B12 imaged in action for first time - Mar 27, 2012
- Inhaling nitric oxide alleviates pain in sickle cell patients - Oct 20, 2010
- Hot springs of volcanic crater in Siberia reveals ancient ecology - Apr 27, 2011
- New medical weapons against anthrax attacks - Jun 24, 2010
- Carbon monoxide can kill in minutes - Feb 14, 2011
- Carbon monoxide can protect against arterial clotting - Jun 24, 2009
- New way to inject oxygen excites medical science - Jun 30, 2012
- Now, a blood test to detect organ transplant rejection - Sep 25, 2010
- Amazing jab cuts down damage in heart attack by 60 percent - Apr 19, 2011
- Grapefruit juice boosts cancer drugs' efficacy - Aug 08, 2012
- Molecule from shark cartilage fights joint pain - Sep 18, 2011
- Scientists create jewel-toned organic phosphorescent crystals - Feb 15, 2011
- Nano drug delivery to eliminate transplant failures - Jan 27, 2012
- Sunlight linked to drug's effectiveness - Mar 10, 2011
Tags: brian mann, carbon monoxide, conventional method, defensive systems, epsrc, macrophages, molecules, physical sciences research, physical sciences research council, professor brian, release co, rms, sciences research council, small doses, target