Breast milk antibodies help neutralize HIVMay 23rd, 2012 - 3:07 pm ICT by IANS
Washington, May 23 (IANS) Antibodies isolated from infected mothers’ breast milk can inhibit the virus that causes AIDS, says a new discovery.
HIV-1 can be transmitted from mother to child via breastfeeding, posing a challenge for safe infant feeding practices in areas of high HIV-1 prevalence. But only one in 10 HIV-infected nursing mothers is known to pass the virus to their infants.
“That is remarkable, because nursing children are exposed multiple times each day during their first year of life,” said senior author Sallie Permar, assistant professor of paediatrics and infectious diseases at Duke University Medical Centre (DUMC).
“We are asking if there is an immune response that protects 90 percent of infants, and could we harness that response to develop immune system prophylaxis (protection) during breastfeeding for mothers infected with HIV-1,” Permar, who led the study, was quoted as saying in the journal Public library of Science.
“Our work helped establish that these B-cells in breast milk can produce HIV-neutralizing antibodies, so enhancing the response or getting more mucosal B-cells to produce those helpful antibodies would be useful, and this is a possible route to explore for HIV-1 vaccine development,” Permar said, according to a university statement.
“This is important work that seeks to understand what a vaccine must do to protect babies from mucosal transmission during breastfeeding,” said Barton Haynes, M.D., study co-author and a national leader in AIDS/HIV research who is also director of the Intre for HIV/AIDS Vaccine Immunology (CHAVI), as well as director of the Duke Human Vaccine Institute (DHVI).
“The antibodies isolated are the first HIV antibodies isolated from breast milk that react with the HIV-1 envelope, and it important to understand how they work to attack HIV-1,” added Haynes.
- Why so many antibodies turn out to be ineffective in blocking HIV infection - Nov 19, 2010
- 6-month drug regimen 'reduces HIV risk for breastfeeding infants' - Mar 03, 2011
- Biological catch-22 prevents generation of HIV blocking antibodies - Dec 16, 2009
- Promising target for AIDS vaccine identified - Apr 01, 2011
- Breast milk promotes gut bugs that give baby immunity - Aug 28, 2012
- Tweaking antibody could lead to vaccine against HIV - May 08, 2011
- Breastfeeding can benefit even the sickest babies - Oct 28, 2010
- Infants 'at risk for measles in first year' - May 19, 2010
- H1N1 pandemic flu strain 'key to universal vaccine' - Jan 11, 2011
- New approach to fight HIV could spur vaccine development - Sep 28, 2010
- Flu jabs during pregnancy lower virus risk to baby - Oct 06, 2010
- Babies insufficiently breastfed, finds study - May 02, 2011
- China to create alternative to human breast milk - Apr 15, 2011
- Anti-hepatitis A shot effective for 10 years - Aug 10, 2012
- Babies breastfed for six months ward off infections - Sep 28, 2010
Tags: aids hiv, aids vaccine, b cells, breast milk, duke university medical, duke university medical centre, hiv aids, hiv antibodies, hiv research, human vaccine, infectious diseases, national leader, neutralizing antibodies, new discovery, nursing mothers, paediatrics, public library of science, university medical centre, vaccine development, vaccine institute