Aspirin may only be protecting men’s heartsNovember 14th, 2007 - 2:26 am ICT by admin
For the study, the research team examined the results of 23 previously published clinical trials for the effect for aspirin in heart attack prevention, involving more than 113,000 patients.
The authors then analysed how much the ratio of men to women in these trials affected the trials’ outcomes.
“Trials that recruited predominantly men demonstrated the largest risk reduction in non-fatal heart attacks,” Dr Don Sin, co-author of the study, said.
“The trials that contained predominately women failed to demonstrate a significant risk reduction in these non-fatal events. We found that a lot of the variability in these trials seems to be due to the gender ratios, supporting the theory that women may be less responsive to aspirin than men for heart protection,” Dr Sin added.
The mechanisms of this resistance are not yet understood, although recent studies have shown that men and women have major differences in the structure and physiology of the heart’s blood vessels.
“From our findings we would caution clinicians on the prescribing aspirin to women, especially for primary prevention of heart attacks,” Dr Sin said.
“Whether or not other pharmaceutical products would be more effective for women is unclear; more sex-specific studies should now be conducted,” Dr Sin added.
The latest study is published in the online open access journal BMC Medicine. (ANI)
- Stress management program benefits patients with heart disease - Jan 25, 2011
- Why folic acid won't prevent a heart attack - Feb 03, 2011
- Aspirin lowers risk of cancer mortality - Aug 12, 2012
- Heart attack risk higher for women whose mothers had strokes - Feb 02, 2011
- Doctors warn that fat can kill even if person is healthy - Feb 15, 2011
- 'Muscle cramp drug better than aspirin in preventing strokes' - Sep 12, 2010
- Painkiller can boost breast cancer survival rates - Feb 18, 2010
- Stress could tell harder on women's hearts - Apr 25, 2012
- Aspirin really can save lives, say Oz researchers - Sep 14, 2010
- Daily aspirin dose cuts cancer risk in elderly - Aug 11, 2012
- 'Aspirin resistance' behind lack of clinical aspirin benefit on heart attacks - May 05, 2010
- Dark chocolate reduces risk of cardiac fatalities - Jun 04, 2012
- Experts discourage younger diabetic patients from using Aspirin - Jun 02, 2010
- Women with gout more likely to have heart attack than men - Feb 08, 2010
- High and low dose aspirin can protect heart - Mar 27, 2012
Tags: aspirin, bmc, clinicians, dr don, fatal heart, gender ratios, heart attack prevention, heart attacks, heart protection, james hogg, open access, pharmaceutical products, physiology of the heart, predominately, primary prevention, pulmonary research, recent studies, risk reduction