Anti-inflammation protein may harbour multiple sclerosis cure

November 14th, 2007 - 10:30 am ICT by admin  

The study at Jefferson Medical College of Thomas Jefferson University and the Jefferson Hospital for Neuroscience in Philadelphia has claimed that the immune system messenger molecule may be an effective tool against MS as it blocks the onset or reverses systems in animals with MS-like diseases.

The research involved an animal model of MS called experimental autoimmune encephalomyelitis (EAE) for investigation.

The study shows the possibility that IL-27 may someday be part of a therapy to temper over-active immune responses, which are thought to be at the heart of MS, an autoimmune disease (in which the body attacks its own tissue) affecting the central nervous system.

The authors said that one of the most common neurological diseases affecting young adults is the myelin coating of nerve fibers which becomes inflamed and scarred. As a result, “messages” could not be sent through the nervous system.

As a result of which the authors tried to find the mechanism how immune response damaged the myelin sheath and axons in the brain. They had earlier observed that a signaling molecule called a cytokine, could suppress IL-17, another cytokine, and inflammation. They also knew that in other MS models, mice that lacked receptors for IL-27 developed excessive inflammation.

While the researchers gave IL-27 to the experimental mice, it showed suppressed active diseases. They witnessed similar effects from IL-27 in cultured cells that were transferred into “na

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