Amazon rainforest natural product may help block tissue destructionNovember 14th, 2007 - 2:48 am ICT by admin
According to the researchers, the extract is an extremely powerful antioxidant that prevents the destruction of human cartilage by molecular s scissors called matrix metalloproteinases (MMPs). These enzymes cut collagen, which forms the backbone of the cartilage, into tiny pieces during states of inflammation and alter the fabric that holds tissues together, they say.
“This is an exciting finding,” said Tariq Haqqi, professor of medicine at Case Western Reserve University/University Hospitals of Cleveland and the lead investigator and senior author of the study.
“This is the first time a natural product has been shown to directly block these molecular scissors while showing potential to stimulate repair. This is a testament to the wound healing properties of this traditional medicine and the distinctive therapeutic opportunities that nature offers,” he added.
Haqqi’s research partner, Rainforest Nutritionals Inc., of Raleigh, N.C., develops innovative therapeutics from natural products and worked with the university on the discovery of Progrado.
Paul Bobrowski, co-author of the study and vice president of Rainforest Nutritionals, said Progrado’s molecular targets are highly prized and could lead to a range of therapeutic innovations for conditions ranging from arthritis, irritable bowel disease and wrinkles based on their involvement in tissue injury/repair and aging.
“The publication of these results reflects the commitment that Rainforest Nutritionals has to scientific excellence and innovation using products derived from nature to promote health and an improved quality of life,” Bobrowski said.
The study is published in the Journal of Inflammation. (ANI)
- Frankincense could be an answer to treating painful joints - Jun 22, 2011
- Tumeric derivative found promising in tendinitis - Aug 11, 2011
- New imaging technique sheds light on inflammation - Oct 16, 2010
- Prebiotic helps lower colon cancer risk: study - May 04, 2012
- Inflammation drug promising in depression - Sep 04, 2012
- Cashew seed extract could help diabetics - Jul 15, 2010
- Use of local anaesthetics can benefit inflammatory bowel disease sufferers - Jul 08, 2010
- How deficiency of a protein results in fragile bones - Jul 28, 2010
- Protein that contributes to ulcerative colitis revealed - Apr 02, 2011
- Synthetic protein to help regenerate new tissues - Sep 11, 2011
- New nanoscopic material promotes cartilage growth - Feb 02, 2010
- DNA sections linked to osteoarthritis found - Jul 03, 2012
- New probiotic fights inflammatory bowel diseases - Feb 01, 2011
- Orally administered nanoparticles to treat inflammatory bowel diseases - Oct 11, 2010
- Immune system can abort stem cell regeneration - Nov 21, 2011
Tags: amazon rainforest, cartilage, case western reserve university, gastrointestinal diseases, inflammation, irritable bowel disease, irritable bowel syndrome, matrix metalloproteinases, medicine, molecular scissors, molecular targets, natural product, nutritionals inc, osteoarthritis, research partner, therapeutic opportunities, tiny pieces, tissue destruction, tissue injury, university hospitals of cleveland