Vitamin D, parathyroid hormone levels ‘don’t affect cardiovascular mortality’
December 16th, 2010 - 3:15 pm ICT by ANIWashington, Dec 16 (ANI): A new research has found that there is no link between serum levels of vitamin D or parathyroid hormone and cardiovascular mortality.
Researchers collected data from the Rancho Bernardo study, which was established in 1972.
Between 1997 and 1999, 1091 participants attended a follow-up visit where blood samples were collected, along with detailed surveys of medical history, medications, cigarette smoking, alcohol consumption, and exercise.
In populations with chronic kidney disease, low levels of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D, and high levels of intact parathyroid hormone have been suggested to explain the association between chronic kidney disease and cardiovascular mortality.
Even in people with intact kidney function, there are multiple mechanisms that could link Vitamin D and cardiovascular disease.
“To our knowledge, this is the first prospective study to investigate the role of serum 25[OH]D, 1,25[OH]2D, and intact parathyroid hormone in the prediction of cardiovascular mortality in a population of older community-dwelling adults with a low prevalence of vitamin D deficiency and a broad range of kidney function,” said lead investigator Simerjot K. Jassal, of the University of California.
He continued, “After adjusting for age alone, there was no independent association between serum levels of 25(OH)D, 1,25(OH)2D, or intact parathyroid hormone and cardiovascular mortality.”
“Prior published literature in community-dwelling adults suggests an increased risk of cardiovascular mortality only in individuals with vitamin D levels lower than levels observed here. Our null results may mean that only larger disruptions in levels of 25(OH)D and 1,25(OH)2D contribute to cardiovascular mortality.
“These null findings are also compatible with results from randomized clinical trials in which vitamin D supplementation has failed to prevent cardiovascular outcomes, although the doses of vitamin D in these trials may have been too low,” he added.
The study was published in the American Journal of Medicine. (ANI)
- Scientist calls for more research into vitamin D's link with Alzheimer's, vascular dementia - May 27, 2009
- Lack of vitamin D linked to metabolic syndrome in elderly people - Jul 02, 2010
- No clear link between lack of vitamin D and depression - Mar 18, 2009
- Vitamin D deficiencies linked to onset of autoimmune lung disease - Jan 04, 2011
- High Vitamin D levels 'may prevent age-related vision loss' - Apr 12, 2011
- Vigilance against skin cancer may lead to vitamin D deficiency - Oct 19, 2010
- Majority of obese teens are vitamin D deficient - Apr 28, 2011
- Vitamin D2 effectively treats vitamin D deficiency - Oct 27, 2009
- Low vitamin D levels 'up respiratory infections in newborns' - Dec 27, 2010
- Sunshine vitamin key to a long and healthy life - Jun 24, 2008
- Vitamin D deficiency widespread across India - Dec 14, 2010
- Vitamin D deficiency linked to high BP, stiffer arteries - Apr 04, 2011
- Gene variant that influences chronic kidney disease identified - Mar 10, 2011
- Low vitamin D levels up death risk - Aug 12, 2008
- Vitamin D deficiency may cause infertility - Feb 03, 2012
Tags: alcohol consumption, blood samples, cardiovascular disease, cardiovascular mortality, cardiovascular outcomes, chronic kidney disease, cigarette smoking, disruptions, independent association, intact parathyroid hormone, kidney function, medical history, null results, parathyroid, parathyroid hormone levels, prospective study, rancho bernardo, randomized clinical trials, serum levels, vitamin d deficiency