Tastes like yogurt? It’s a vaccineMarch 18th, 2009 - 5:28 pm ICT by IANS
Washington, March 18 (IANS) Instead of dreaded injections, getting vaccinated against disease may become as tasty as drinking a yogurt smoothie.
A researcher from the Northwestern University Feinberg School of Medicine has developed a new oral vaccine using probiotics, the healthy bacteria found in dairy products like yogurt and cheese.
He has successfully used the approach in a preclinical study to create immunity to anthrax exposure. He also is using the method to develop a breast cancer vaccine and vaccines for various infectious diseases.
This new generation vaccine has big benefits beyond eliminating the pain factor. Delivering the vaccine to the gut - rather than injecting it into a muscle - harnesses the full power of the body’s primary immune force, which is located in the small intestine.
There are other advantages to the new oral vaccine. Probiotics, which are natural immune stimulators, eliminate the need for a chemical in traditional vaccines that inflames the immune system and triggers a local immune response.
The chemical in an injected vaccine may cause side effects such as dizziness, arm swelling and vomiting. Probiotic vaccines also are inexpensive to produce.
“This is potentially a great advance in the way we give vaccines to people,” said Mansour Mohamadzadeh, co-author and associate professor of medicine in gastroenterology at the Feinberg School.
“You swallow the vaccine, and the bacteria colonise your intestine and start to produce the vaccine in your gut,” Mohamadzadeh said. “Then it’s quickly dispatched throughout your body. If you can activate the immune system in your gut, you get a much more powerful immune response than by injecting it. The pathogenic bacteria will be eliminated faster.”
Most vaccines consist of protein and won’t maintain their effectiveness after being digested by the stomach. However, the lactobacillus protects the vaccine until it is in the small intestine, said a Northwestern release.
The study appeared in a recent issue of the Proceedings of the National Academy of Science.
- New probiotic fights inflammatory bowel diseases - Feb 01, 2011
- New probiotic can treat irritable bowels - Feb 01, 2011
- Probiotic drinks, yogurts 'do not aid digestion' - Oct 20, 2010
- Healthy bacteria could prevent obesity - May 26, 2011
- Probiotic drinks don't promote health, says EU study - Oct 20, 2010
- Friendly bugs can now be delivered safely to guts - Sep 06, 2011
- Good bacteria in dairy products can help deliver oral vaccine against anthrax - Feb 17, 2009
- Friendly bugs to help you shed weight - Jan 17, 2011
- Intestinal bacteria cause behavioural changes - May 18, 2011
- 'Good bacteria' in yogurt may not be as healthy as you think! - Dec 27, 2010
- Probiotics cut duration of stomach upsets - Nov 11, 2010
- 'Bouncer' protein halts rheumatoid arthritis - Sep 22, 2011
- Stress levels can lower immunity through bacteria - Mar 22, 2011
- Probiotic can't help in diarrhoea caused by Salmonella - Apr 20, 2010
- Immune cells that act as 'body's border patrol' identified - Feb 08, 2011
Tags: anthrax, breast cancer, breast cancer vaccine, co author, dairy products, feinberg school of medicine, gastroenterology, generation vaccine, immune response, immune stimulators, infectious diseases, lactobacillus, northwestern university feinberg school of medicine, oral vaccine, pathogenic bacteria, school of medicine, small intestine, traditional vaccines, vaccinated, yogurt