Study finds enzyme that gives rats better long-term memories
March 4th, 2011 - 4:16 pm ICT by ANIWashington, Mar 4 (ANI): A new study has found that increased levels of a natural brain enzyme gives rats better recall of old remembrances.
A U.S.-Israeli team has found that they could make rats forget a range of old learned behaviours by blocking the protein called PKM-zeta in the brain.
Rodents with too little PKM-zeta, for instance, didn’t know to avoid liquids that had made them sick in the past.
“If you, indeed, can block the memory by blocking the enzyme, can you enhance the memory by enhancing the enzyme?” Discovery News quoted Yadin Dudai, a neurobiologist at the Weizmann Institute of Science in Rehovot, Israel, as saying.
The rodents didn’t instantly recall where they left that cheese, though. Researchers trained the rats to associate certain tastes — like sugary or salty — with gross feelings akin to mild food poisoning. Rats that received the enzyme boost remembered to steer clear of those tastes much better than control rats did.
Also, the taste training had taken place days before the injections, so the enzymes gave a kick to memorable experiences.
The find may have implications for memory-related medicine research. either to jog good memories or — in patients with post-traumatic stress disorder, say — help people forget bad ones, Glanzman said.
However, he said there’s still a long way to go and more studies are required in order to understand better how the enzyme works.
“You have to know where the memory is in the brain. We don’t have a very good way to do that right now.
“There’s a reason why the brain keeps memory under tight regulation.”
The study appears in the March 5 Science. (ANI)
- Enzyme enhances, erases rat's long-term memories - Mar 06, 2011
- Scientists discover way to reduce traumatic memories - Apr 28, 2011
- Can traumatic memories be erased? - Apr 28, 2011
- Neural mechanisms of courage uncovered - Jun 24, 2010
- Nerve cell memory holds key erasing pain - Feb 14, 2012
- Scientists find protein that boosts memory, prevents forgetfulness - Feb 03, 2011
- How those 'Aha' moments are imprinted in memory - Apr 02, 2011
- How some aromas are bound up in our memories - Nov 10, 2009
- Star-shaped brain cells 'essential for making long-term memories' - Mar 04, 2011
- Potential therapeutic target for improving long-term memory identified - Jan 27, 2011
- Novel approach could benefit stroke victims - Feb 09, 2011
- Memory booster pill for the elderly in the offing - Oct 13, 2010
- Mole-rats' secret can help brain survive in oxygen scarcity - Feb 27, 2012
- Stress can improve ordinary, unrelated memories: Study - Dec 22, 2010
- Protein that turns off stress identified - Feb 09, 2011
Tags: brain enzyme, control rats, discovery news, enzyme discovery, israeli team, learned behaviours, medicine research, memorable experiences, mild food poisoning, neurobiologist, pkm, post traumatic stress, post traumatic stress disorder, rehovot israel, remembrances, rodents, term memories, tight regulation, traumatic stress disorder, weizmann institute of science