Study examines aspirin’s ability to protect against colorectal cancerMarch 10th, 2011 - 11:35 am ICT by ANI
Washington, Mar 10 (ANI): A new study says that elevations in a particular inflammatory factor in the blood may determine whether colorectal cancer risk can be reduced by taking aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs).
“These findings suggest that a blood biomarker may be helpful in deciding whether individuals should take aspirin or NSAIDs to reduce their cancer risk,” said Andrew Chan at Massachusetts General Hospital.
“They also indicate that chronic inflammatory pathways are quite complex and further studies are needed to understand which facets of the inflammatory response are most associated with the development of colorectal cancer.”
The investigators analyzed data from the Nurses Health Study (NHS), which has followed more than 120,000 female registered nurses since 1976, gathering comprehensive health information from its participants every two years.
After identifying 280 participants who developed colorectal cancer during the subsequent 14 years and 555 age-matched controls who did not, the research team analyzed their baseline levels of three inflammatory factors - C-reactive protein (CRP), interleukin-6 (IL-6) and soluble tumor necrosis factor receptor-2 (sTNFR-2).
They found that participants with the highest levels of sTNFR-2 had a 60 percent greater risk than did those with the lowest levels of the factor.
Those with high baseline sTNFR-2 levels showed reduced risk of developing colorectal tumors associated with regularly taking aspirin or NSAIDs.
“Our results suggest that, even though chronic inflammation may increase colorectal cancer risk, not all blood markers of inflammation are markers of that risk,” said Chan.
“The most common blood biomarkers of inflammation - CRP and IL-6 - do not appear to be relevant, while sTNFR-2 does. A better understanding of the significance of these markers will help us identify individuals most likely to benefit from chemoprevention using aspirin or NSAIDs.”
The study appears in the March issue of Gastroenterology. (ANI)
- Blood test for inflammation could also show risk for colon cancer - Apr 20, 2010
- Dormant virus might make you diabetic - Aug 28, 2012
- New aspirin curbs 11 kinds of cancer, shrinks tumours - Mar 09, 2012
- Aspirin 'cuts bowel cancer risk' - Sep 16, 2010
- Poor sleep ups risk of heart disease, stroke: Study - Nov 15, 2010
- Tart cherries may reduce inflammation, risk factors for heart disease - Apr 13, 2011
- High consumption of omega-3s 'cuts obesity-related disease risk' - Mar 25, 2011
- Higher levels of folate in RBCs linked to silenced tumor-suppressors - Dec 23, 2010
- Chronic inhalation of polluted air 'can lead to inflammation, heart risk' - Apr 17, 2011
- Chronic brain inflammation 'linked to memory loss in older adults' - Apr 14, 2011
- Ibuprofen may reduce risk of Parkinson's disease - Mar 03, 2011
- Aspirin may cut the risk of pancreatic cancer - Apr 05, 2011
- Inflammation drug promising in depression - Sep 04, 2012
- Now, simple blood test to help predict chronic kidney disease - Oct 22, 2010
- Aspirin 'cuts colorectal cancer death risk' - Aug 12, 2009
Tags: andrew chan, anti inflammatory drugs, baseline levels, biomarker, blood markers, c reactive protein, cancer risk, chronic inflammation, colorectal cancer, colorectal tumors, factor receptor, health study, inflammatory response, interleukin 6, massachusetts general hospital, nonsteroidal anti inflammatory drugs, nsaids, nurses health, registered nurses, tumor necrosis factor