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Washington, May 04 (ANI): Results of an analysis of previous studies have indicated that implementing structured exercise training, including aerobic, resistance or both, was associated with a greater reduction in hemoglobin A1c levels (a marker of glucose control) for patients with diabetes compared to patients in the control group, and longer weekly exercise duration was also associated with a greater decrease in these levels.

Daniel Umpierre, of the Hospital de Clinicas de Porto Alegre, Brazil, and colleagues performed a systematic review and meta-analysis of previously conducted randomized controlled clinical trials (RCTs) of at least 12 weeks’ duration that evaluated the ability of structured exercise training or physical activity advice to lower hemoglobin A1c (HbA1c) levels as compared with a control group in patients with type 2 diabetes.

The researchers identified 47 RCTs (8,538 patients) that met criteria for inclusion.

The researchers found that overall, structured exercise training (23 studies) was associated with a decline in HbA1c level (-0.67 percent) compared with control participants. In addition, structured aerobic exercise (-0.73 percent), structured resistance training (-0.57 percent), and both combined (-0.51 percent) were each associated with declines in HbA1c levels compared with control participants.

“Structured exercise durations of more than 150 minutes per week were associated with HbA1c reductions of 0.89 percent, while structured exercise durations of 150 minutes or less per week were associated with HbA1c reductions of 0.36 percent. Overall, interventions of physical activity advice (24 studies) were associated with lower HbA1c levels (-0.43 percent) compared with control participants. Combined physical activity advice and dietary advice was associated with decreased HbA1c (-0.58 percent) as compared with control participants. Physical activity advice alone was not associated with HbA1c changes,” said the authors.

“This systematic review and meta-analysis of RCTs demonstrates important findings regarding the prescription of structured exercise training. First, aerobic, resistance, and combined training are each associated with HbA1c decreases, and the magnitude of this reduction is similar across the 3 exercise modalities. …”

“Second, our findings demonstrate that structured exercise of more than 150 minutes per week is associated with greater declines in HbA1c than structured exercise of 150 minutes or less per week in patients with type 2 diabetes. This finding is important because the current guideline-recommended exercise duration is at least 150 minutes per week. Although high-intensity exercise has been previously shown to have an association with HbA1c reduction, our findings did not demonstrate that more intensive exercise was associated with greater declines in HbA1c,” added authors.

Results of an analysis have been published in the JAMA. (ANI)