Steroid nasal spray safe, effective against chronic rhinosinusitis

March 17th, 2009 - 4:35 pm ICT by ANI  

Washington, Mar 17 (ANI): A steroid nasal spray has been found to reduce symptoms of chronic rhinosinusitis, according to a new study led by Indian origin scientist.

Researchers led by Neil S. Sachanandani from Washington University School of Medicine have found that an aqueous nasal spray containing corticosteroid budesonide has been shown to be safe and beneficial for those with chronic rhinosinusitis and recurring allergies.

It appears to reduce symptoms of rhinosinusitis without suppressing the function of the adrenal glands, a known complication of this type of drug that would indicate absorption throughout the whole body.

During the study, Sachanandani assessed the effects of budesonide on adrenal function in nine patients between 2005 and 2006.

The participants were instructed to use a nasal wash composed of 0.25 milligrams of budesonide and 5 milliliters of saline in each nostril once daily for 30 days.

The researchers found that all patients showed an adequate adrenal response to cosyntropin before and after budesonide therapy.

All patients “reported some form of overall improvement with the use of budesonide, and six of the nine patients (67 percent) would recommend this drug to a friend,” the authors write.

“The clinical significance of this study is that budesonide nasal respules appear safe for short-term use for the relief of symptoms associated with chronic sinusitis,” they said.

“Budesonide respules seem to provide an effective treatment option for the patient with chronic rhinosinusitis with minimal fear of systemic adverse effects,” they added.

The study appears in Archives of OtolaryngologyHead & Neck Surgery, one of the JAMA/Archives journals. (ANI)

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