Stem cell transplant in embryo protects mice from cardiac injury in adulthoodMay 15th, 2009 - 4:29 pm ICT by ANI
Washington, May 15 (ANI): Stem cells, when transplanted into mouse embryos, have been found to halt or reverse cardiac injury after heart attack in adulthood, according to a new study.
The researchers involved in the study delivered embryonic stem cells to mouse embryos in the earliest stages of development, and found that the resulting mice demonstrated a capacity to recover from cardiac injury in adulthood.
The study provides the first evidence that preventive regenerative medicine can successfully be used to treat myocardial infarction through prophylactic intervention.
Led by Dr. Andre Terzic of the Mayo Clinic, researchers injected mouse embryos with embryonic stem cells that had been used to successfully treat ischemic heart disease following heart attack.
The resulting animals incorporated between five and 20 percent of labelled stem cell-derived tissue.
They were born with no apparent abnormalities, and the tested and control groups had similar overall baseline cardiac disease risk profiles and demonstrated similar cardiac performance during the one-year follow-up.
In both the groups, researchers induced cardiac injury by tying off the left anterior artery, causing complete coronary blockage.
It was found that the group that had received the embryonic stem cell treatment recovered cardiac function, while the other group deteriorated, demonstrating ischemic myopathy, myocardial scarring and significant pulmonary congestion, usually seen in the progression towards heart failure.
On the whole, the group treated with stem cells displayed a favourable disease course, with superior exercise workload capacity and stress test performance, as well as increased survival.
“Preemptive stem cell-based intervention in utero thus provides a strategy to engineer tolerance, and prevent incidence of life-threatening organ failure in the adult,” said the authors.
They concluded that beyond reconstructive surgery, stem cell transplantation in prenatal development could offer an innovative approach for preventing disease.
The study has been published in Stem Cells. (ANI)
- Stem cells transplanted into mice embryo protect heart - May 15, 2009
- 'Grafting helps normalise heartbeats' - Aug 06, 2012
- 'Smart' adult stem cells repair heart in 'landmark work' - Aug 17, 2010
- New stem cells could help heal damaged hearts - Dec 23, 2011
- Paralysed patient becomes world's first to get stem cell therapy - Oct 12, 2010
- Stem cells from diseased hearts can treat cardiac failure - Nov 22, 2010
- Embryo stem cell therapy brings hope to those with incurable diseases - Jun 10, 2012
- Enzyme essential for healthy lung development discovered - Mar 30, 2011
- Scientists grow heart cells in lab - Nov 03, 2011
- Menstrual blood stem cells can treat many ailments - May 04, 2011
- London hospital to do Europe's first embryonic stem cell trial - Sep 24, 2011
- Stem cell regulations shouldn't stifle research: Indian experts - Apr 21, 2011
- Stem cells from aged, damaged hearts could be used to treat heart failure - Nov 18, 2010
- How to heal a broken heart - Apr 13, 2010
- Scientists create retina from human embryonic stem cells - May 27, 2010
Tags: cardiac disease, cardiac function, cardiac injury, cardiac performance, control groups, embryonic stem cell, embryonic stem cell treatment, embryonic stem cells, first evidence, heart failure, mayo clinic researchers, mouse embryos, myocardial infarction, organ failure, pulmonary congestion, regenerative medicine, risk profiles, stem cell transplant, stress test, test performance