Special sugar, nanoparticles may help detect cholera toxin
January 19th, 2011 - 6:42 pm ICT by ANIWashington, Jan 19 (ANI): Scientists at the University of Central Florida have developed a technique that may someday become one of the most effective weapons to stop the spread of cholera, a disease that has claimed thousands of lives in Haiti since the devastating earthquake last year.
The technique would allow relief workers to test water sources that could be contaminated with the cholera toxin.
In the test, the sugar dextran is coated onto iron oxide nanoparticles and then added to a sample of the water. If the cholera toxin is present, the toxin will bind to the nanoparticles’ dextran. This is because dextran looks similar to the cholera toxin receptor (GM1) found on cells’ surface in the victim’s gut.
The technique likely would be less expensive than those currently available, and it would provide results more quickly, enabling workers to restrict access to contaminated sources and limit the spread of the disease.
“It’s really quite amazing,” said UCF assistant professor J. Manuel Perez, the lead researcher on the project. “It means we have a quicker diagnostic tool using a simple and relatively cheap sugar-nanoparticle combination.”
Early studies also show that the technique could someday be used to treat someone infected with cholera, which is caused by poor sanitation and dirty water, and potentially other diseases, Perez said.
More studies are needed to prove the adaptability of the technique, but its impact could be huge. In countries with poor sanitation, outbreaks caused by drinking contaminated water often prove fatal. Deadly toxins also can result from bioterrorism or food contamination.
There are an estimated 3 million to 5 million cholera cases, and 100,000 to 120,000 deaths, worldwide each year, according to the World Health Organization. A cholera outbreak has killed more than 3,000 people in Haiti since the earthquake, and WHO warned earlier in January that the outbreak has not yet reached its peak.
Research findings appear online today in the journal Bioconjugate Chemistry. (ANI)
- Toward a fast, simple test for detecting cholera - Feb 10, 2011
- Ghana cholera toll rises to 21 - Apr 19, 2012
- Google GPS, gene sequencing combo tracks typhoid outbreaks - Oct 17, 2011
- Aid for Haiti a priority as 600,000 still live in camps following quake - Oct 06, 2011
- Cholera claimed 4,000 lives in Haiti - Jan 26, 2011
- Haiti's cholera strain came from South Asia: Study - Dec 11, 2010
- Haiti cholera deaths top 1,500 - Nov 26, 2010
- Haiti cholera toll rises to 500 - Nov 07, 2010
- 10 killed in cholera outbreak in Uganda - Jun 17, 2010
- Cholera epidemic kills 11 in Ghana - Apr 05, 2012
- Cholera Claims About 800 Lives In West Africa - Sep 11, 2010
- Haitian fear widespread epidemic as cholera outbreak death toll in Haiti surpasses 250 - Oct 25, 2010
- Haiti cholera toll reaches 3,651 - Jan 07, 2011
- Cholera outbreak: 2,000 evacuated from Haiti refugee camp - Nov 06, 2010
- Cholera in Assam tea gardens: 16 killed, 150 affected - Oct 27, 2010
Tags: adaptability, bioterrorism, cholera cases, cholera outbreak, cholera toxin, contaminated water, deadly toxins, devastating earthquake, dextran, diagnostic tool, dirty water, food contamination, iron oxide, jan 19, manuel perez, poor sanitation, relief workers, university of central florida, water sources, world health organization