Soon, a ‘nano drug’ jab that hits brain tumour’s bullseye
November 6th, 2010 - 2:41 pm ICT by ANIWashington, Nov 6 (ANI): The scientists have developed a unique technology, which can inject anti-tumor drugs directly into brain tumor cells, unlike other drugs of its kind.
The research team at Cedars-Sinai’s Maxine Dunitz Neurosurgical Institute has created a ‘nanobioconjugate’ drug that may be given by intravenous injection and carried in the blood to target the brain tumor.
It is engineered to specifically permeate the tumor cell wall, entering endosomes, mobile compartments within cells.
Studies in lab mice showed this system allows large amounts of antitumor drug to accumulate in tumors, significantly slowing the growth of new vessels and the tumors themselves.
“This nanobioconjugate is different from earlier nanomedicine drugs because it delivers and releases antitumor drugs within tumor cells, not just at the site of a tumor,” said research scientist Julia Y. Ljubimova, senior author of the article.
“Based on our studies, this nanoconjugate appears to be a safe and efficient delivery platform that also may be appropriate in the treatment of degenerative brain conditions and a wide array of other disorders,” she added.
Researchers anticipate that human clinical trials of the drug will begin in the near future. (ANI)
- New 'nanodrug' can attack breast cancer cells from the inside out - Mar 30, 2011
- Erectile dysfunction drug could enhance delivery of herceptin to brain tumours - May 08, 2010
- Drug from Indian spice builds brain cells after stroke - Feb 10, 2011
- New hybrid drug, derived from turmeric, may benefit stroke victims - Feb 10, 2011
- Compound derived from turmeric has neuroprotective effects - Dec 16, 2010
- Mechanism in cells forming brain tumours may offer target for gene therapy - Oct 25, 2008
- Study identifies immune system 'trigger' that fights disease - Apr 30, 2011
- New drug shows promise against ovarian and breast cancer - Aug 13, 2010
- Viagra may help cancer-fighting drugs reach malignant brain tumours - Jul 29, 2008
- New methods identify, manipulate ''newborn'' cells in Parkinsons patients - Sep 04, 2008
- Scientists uncover gene therapy to eliminate brain tumours - Jan 13, 2009
- Scientists pinpoint deadly brain tumor's origin - Jan 08, 2011
- How white blood cells detect, destroy invaders - May 01, 2011
- Vaccines for heart attacks to be ready within 5 years - Apr 01, 2012
- Dr. Keith Black Awarded BET Honors Award For Public Service - Feb 02, 2010
Tags: antitumor drugs, array, brain conditions, brain tumor, brain tumour, bullseye, cedars sinai, delivery platform, dunitz, human clinical trials, intravenous injection, jab, lab mice, maxine dunitz neurosurgical institute, research scientist, scientists, tumor cell, tumor cells, tumors, unique technology